Development of the inner ear and regeneration of hair cells after hearing impairment  

作　　者：Xin Bing Chengcheng Liu Xue Cao Chengzhilin Li Xiaochen Gao Fangyuan Zhu Xinhao Wu Na Guo Houyang Hu Ming Xia Miaoqing Zhao 

机构地区：[1]Department of Pathology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117,China [2]Department of Otolaryngology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China [3]Department of Otolaryngology,Shandong Provincial Hospital,Shandong University,Jinan 250021,China [4]Department of Central Laboratory,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China [5]NHC Key Laboratory of Otorhinolaryngology,Jinan 250021,China [6]Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 271000,China

出　　处：《Fundamental Research》2025年第1期203-214,共12页自然科学基础研究(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(82071013,82071035,82371165);Natural Science Foundation of Shandong Province(ZR2022LZL001);Joint Fund of Shandong Province(ZR202ILSW028);Taishan Scholar Foundation of Shandong Province(tsqn201812134).

摘　　要：Hearing loss,as a sensory disorder,is the most common occurrence among humans,which has received increasing attention from society.It is mainly caused by the damage of inner ear hair cells(HCs)or the degeneration of spiral ganglion neurons.In mammals,cochlear HCs cannot regenerate naturally after injury,leading to irreversible hearing loss.Therefore,HCs are essential for hearing protection.In recent years,the protection of drug-related ototoxicity,inner ear stem cells,gene therapy,new materials,and signal regulation have become important ways to develop regeneration strategies of HCs.An in-depth study of the causes of the occurrence and development of hearing impairment and the regeneration of hearing loss for effective prevention,discovery,and treatment of deafness has great significance.This review aimed to analyze the development of the inner ear and summarize the related factors leading to HCs injury and the research progress of regeneration after injury.

关 键 词：DEVELOPMENT Hearing impairment Hearing protection Inner ear hair cells REGENERATION 

分 类 号：R76[医药卫生—耳鼻咽喉科]