End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle  

作　　者：Xiaoyan Hu Jingqi Zeng Lijuan M Xiaomeng Wang Jing Du Lu Yao Zhisheng Wu 

机构地区：[1]Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China [2]Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development,Ministry of Education,Beijing 100102,China [3]Beijing University of Chinese Medicine,Beijing 100102,China [4]China Beijing Tongrentang Group Co.,Ltd.Beijing 100062,China

出　　处：《Fundamental Research》2025年第1期407-418,共12页自然科学基础研究(英文版)

基　　金：co-supported by Excellent Young Scientists Fund of National Natural Science Foundation of China(82022073);Major scientific and technological R&D projects in Jiangxi Province(20203ABC28W018);National Natural Science Foundation of China(82274110);the Fundamental Research Funds for the Central Universities(2022-JYB-JBZR-018,2022-JYB-JBZR-019).

摘　　要：This study reported an original end-to-end dataflow engineering framework for the quality transfer principle to overcome the quality challenges in real-world honey manufacturing.Firstly,650 pivotal data points of physical and chemical quality attributes from 65 batches of honey intermediates were characterized through multiple sensors,which included rheological properties,acidity,moisture,and sugars.Furthermore,a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey,the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered(KD<1×10^(−8)M),and the abnormal batches of B2,B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable algorithm.Finally,the end-to-end dataflow containing physical,chemical and biological critical quality attributes was successfully established to interpret the quality transfer principle of honey manufacturing,which revealed that the front-end refining process was relatively unstable and the back-end refining process was a negligible influence on the quality of honey manufacturing.This framework embraces quality management,quality transfer,and biosensor information,which will contribute to discovering the quality transfer principle in industrial innovation for intelligent manufacturing.

关 键 词：End-to-end dataflow Quality transfer principle Critical quality attributes BIOSENSOR Honey manufacturing 

分 类 号：TP2[自动化与计算机技术—检测技术与自动化装置]