依诺肝素钠结合间苯三酚对先兆流产患者症状消退时间、内分泌指标及凝血功能的影响  

The effects of enoxaparin sodium combined with triphenylphenol on symptom resolution time,endocrine indicators,and coagulation function in patients with threatened miscarriage

作　　者：刘利[1] 袁新荣[1] 黄建清 方小理 李捷[1] Liu Li;Yuan Xinrong;Huang Jianqing;Fang Xiaoli;Li Jie(The First Naval Hospital of the Southern Theater of the Chinese People’s Liberation Army,Zhanjiang,Guangdong 524000,China)

机构地区：[1]中国人民解放军南部战区海军第一医院,广东湛江524000

出　　处：《首都食品与医药》2025年第2期53-56,共4页Capital Food Medicine

摘　　要：目的探究依诺肝素钠结合间苯三酚对先兆流产患者症状消退时间、内分泌指标及凝血功能的影响。方法选择2022年6月-2024年6月本院收治的先兆流产患者88例,按随机数表法分为两组,每组各44例。对照组予以间苯三酚注射液,观察组在对照组的基础上予以依诺肝素钠注射液,两组均连续治疗5d。观察比较两组临床疗效、症状消退时间、内分泌指标、凝血功能、不良反应以及不良妊娠结局发生情况。结果观察组治疗总有效率为93.18%,较对照组77.27%高,观察组症状消退时间腹痛(2.56±0.44)d、阴道出血(2.10±0.51)d以及腰酸(1.92±0.24)d均短于对照组,观察组治疗后雌二醇(E2)(1428.26±45.96)pg/mL、孕酮(P)(38.26±5.21)ng/mL、β-人绒毛膜促性腺激素(β-HCG)(1783.69±105.29)IU/mL均较对照组高,观察组治疗后活化部分凝血活酶时间(APTT)(33.43±3.81)s、凝血酶原时间(PT)(14.66±1.42)s、凝血酶时间(TT)(13.43±1.03)s较对照组高,观察组不良妊娠结局发生率较对照组低,有统计学差异(P<0.05);统计学数据分析两组不良反应,未见明显差异(P>0.05)。结论依诺肝素钠结合间苯三酚治疗先兆流产患者临床疗效确切,能够有效促进患者临床症状消退,调节内分泌指标,改善凝血功能,降低不良妊娠结局发生率,且用药安全性较高。Objective To investigate the effects of enoxaparin sodium combined with triphenylphenol on the time of symptom resolution,endocrine indicators,and coagulation function in patients with threatened miscarriage.Methods 88 patients with threatened miscarriage admitted to our hospital from June 2022 to June 2024 were selected and randomly divided into two groups,with 44 patients in each group,using a random number table.The control group received triphenylphenol injection,while the observation group received enoxaparin sodium injection in addition to the control group.Both groups were treated continuously for 5 days.Observe and compare the clinical efficacy,symptom resolution time,endocrine indicators,coagulation function,adverse reactions,and incidence of adverse pregnancy outcomes between two groups.Results The total effective rate of the observation group was 93.18%,which was higher than the control group’s 77.27%.The observation group had lower abdominal pain(2.56±0.44)days,vaginal bleeding(2.10±0.51)days,and the time for the disappearance of lower back acid symptoms(1.92±0.24)days compared to the control group.After treatment,the observation group had higher levels of estradiol(E2)(1428.26±45.96)pg/mL,progesterone(P)(38.26±5.21)ng/mL,andβ-human chorionic gonadotropin(β-HCG)(1783.69±105.29)IU/mL compared to the control group.After treatment,the observation group had higher activated partial thromboplastin time(APTT)(33.43±3.81)s and prothrombin time(PT)(14.66±1.42)s and thrombin time(TT)(13.43±1.03)s compared to the control group,and the incidence of adverse pregnancy outcomes was lower in the observation group than in the control group,with statistical differences(P<0.05);statistical data analysis showed no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of enoxaparin sodium and phloroglucinol is clinically effective in treating patients with threatened miscarriage.It can effectively promote the resolution of clinical symptoms,regulate endocrine i

关 键 词：先兆流产 依诺肝素钠 间苯三酚 症状消退时间 内分泌指标 

分 类 号：R714.25[医药卫生—妇产科学]