双环醇治疗甲亢及抗甲状腺药物治疗后致肝功能损害疗效观察  

Observation of the efficacy of bicyclol in treating hyperthyroidism and liver function damage caused by antithyroid drug therapy

作　　者：龙恬恬 罗熙文 罗绡 Long Tiantian;Luo Xiwen;Luo Xiao(Foshan Fosun Chancheng Hospital,Foshan,Guangdong 528000,China;Xinyi People’s Hospital,Maoming,Guangdong 525300,China)

机构地区：[1]佛山复星禅城医院,广东佛山528000 [2]广东省信宜市人民医院,广东茂名525300

出　　处：《首都食品与医药》2025年第2期65-67,共3页Capital Food Medicine

摘　　要：目的研究双环醇治疗甲亢及抗甲状腺药物治疗后致肝功能损害疗效。方法选取2022年8月-2023年8月期间本院收治的甲亢患者60例,随机分为复方组[甘草酸二胺肠溶胶囊(天晴甘平)治疗]和双环组(双环醇治疗),每组各30例;比较两组的TPO、TGAb、甲状腺功能指标以及肝功能指标。结果双环组治疗后的TPO、TGAb水平均低于复方组,差异具有统计学意义(P<0.05);双环组治疗后的TSH高于复方组,而FT4、FT3比复方组均更低(P<0.05);治疗后双环组的肝功能各指标均低于复方组,差异显著(P<0.05)。结论甲亢患者经过双环醇治疗效果显著,它不仅对肝脏的负担更小,从而保护了肝脏功能,还能积极促进患者自身免疫系统的恢复,使得治疗过程更加安全。Objective To investigate the efficacy of Bicyclol in treating hyperthyroidism and liver function damage caused by antithyroid drug therapy.Methods Sixty patients with hyperthyroidism admitted to our hospital between August 2022 and August 2023 were randomly divided into a compound group[treated with diammonium glycyrrhizinate enteric-coated capsules(Tianqing Ganping)]and a Bicyclol group(treated with Bicyclol),with 30 patients in each group.The TPO,TGAb,thyroid function indicators and liver function indicators of the two groups were compared.Results The levels of TPO and TGAb in the Bicyclol group were significantly lower than those in the compound group after treatment(P<0.05).The TSH levels in the Bicyclol group were higher,while FT4 and FT3 levels were lower compared to the compound group(P<0.05).The liver function indicators in the Bicyclol group were significantly lower than those in the compound group after treatment(P<0.05).Conclusion Bicyclol has a significant therapeutic effect in patients with hyperthyroidism.It not only imposes a smaller burden on the liver,thereby protecting liver function,but also actively promotes the recovery of the patient’s immune system,making the treatment process safer.

关 键 词：双环醇 甲亢 抗甲状腺药物 肝功能损害 

分 类 号：R581.1[医药卫生—内分泌]