重组人生长激素和谷氨酰胺的强化营养对老年脓毒症患者临床治疗的影响  

Intensive nutrition of recombinant human growth hormone and glutamine in elderly patients with sepsis

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作  者:高淑萍 Gao Shuping(Boai Hospital,Huanghua Development Zone,Cangzhou,Hebei 061100,China)

机构地区:[1]河北省黄骅市开发区博爱医院,河北沧州061100

出  处:《首都食品与医药》2025年第2期74-77,共4页Capital Food Medicine

摘  要:目的探讨重组人生长激素联合谷氨酰胺强化营养干预对老年脓毒症患者的疗效。方法选择2022年2月-2024年3月我院重症医学科收治的120例脓毒症老年患者,将其随机分为对照组和观察组各60例,对照组采取标准营养支持治疗,观察组增加重组人生长激素联合谷氨酰胺强化营养。对比两组患者营养指标、免疫指标、急慢性健康评分、器官功能评分、ICU停留时间、抗生素使用时间、并发症情况。结果观察组血清ALB、PAB高于对照组,P<0.05;观察组IgG、IgM、CD4/CD8高于对照组,且CRP低于对照组,P<0.05。观察组APACHEⅡ、SOFA评分低于对照组,ICU停留时间、抗生素使用时间短于对照组,P<0.05。观察组并发症发生率低于对照组,P<0.05。结论重组人生长激素和谷氨酰胺的强化营养治疗能够显著改善老年脓毒症患者的临床预后。通过促进蛋白质合成、增强免疫功能、维持肠道屏障功能、减少炎症反应等途径,可改善患者的营养状况和器官功能,减少并发症发生率,值得应用。Objective To investigate the effect of recombinant human growth hormone combined with glutamine fortified nutritional intervention on elderly patients with sepsis.Methods A total of 120 elderly patients with sepsis admitted to the intensive care unit from February 2022 to March 2024 in our hospital were randomly divided into a control group and an observation group,with 60 patients in each group.The control group was treated with standard nutritional support,and the observation group was treated with recombinant human growth hormone combined with glutamine.Compared two groups of patients’nutrition,immune,acute or chronic health evaluation,organ function,ICU stay time,antibiotic use time and complications.Results Observation group serum ALB and PAB is higher than the control group,P<0.05;IgG,IgM,CD4/CD8 in the observation group were higher than those in the control group,and CRP was lower than that in the control group,P<0.05.The APACHEⅡ and SOFA scores of the observation group were lower than those of the control group,and the ICU stay time and antibiotic use time were shorter than those of the control group,P<0.05.The incidence of complications in the observation group was lower than that in the control group,P<0.05.Conclusions Intensive nutritional therapy with recombinant human growth hormone and glutamine can significantly improve the clinical prognosis of elderly patients with sepsis.By promoting protein synthesis,enhance immune function,maintain the intestinal barrier function,reduce inflammation,can improve the nutritional status of the patients and organ function,reduce the incidence of complications,worthy of application.

关 键 词:脓毒症 重组人生长激素 谷氨酰胺 强化营养干预 疗效观察 

分 类 号:R631[医药卫生—外科学]

 

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