血常规衍生物NLR、MLR和SIRI在门急诊乙型流感病毒初筛阳性患者中的应用价值  

Application value of blood routine derivatives NLR, MLR and SIRI in patients with positive primary screening for influenza B virus in outpatient and emergency department

作　　者：茆志翔 姚杰[1] 陈津津 陈礼文[1] MAO Zhixiang;YAO Jie;CHEN Jinjin;CHEN Liwen(Laboratory Department,the Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China)

机构地区：[1]安徽医科大学第二附属医院检验科,安徽合肥230601

出　　处：《临床医学研究与实践》2025年第6期49-52,共4页Clinical Research and Practice

基　　金：2024年度安徽省卫生健康科研项目(No.2024Aa20307)。

摘　　要：目的 探讨血常规衍生物中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)和全身炎症反应指数(SIRI)对门急诊乙型流感病毒(IBV)初筛阳性患者的诊断价值。方法 回顾性收集2024年1月于我院门急诊就诊的188例IBV初筛阳性患者纳入观察组,另选取同期在我院进行健康体检的200名健康人为对照组。比较两组及不同性别间的白细胞(WBC)、中性粒细胞(NEUT)、淋巴细胞(LYMPH)和单核细胞(MONO)计数及NLR、MLR、SIRI;采用受试者工作特征(ROC)曲线分析血常规衍生物对不同性别IBV感染的预测效能。结果 观察组的WBC、LYMPH计数低于对照组,NEUT、MONO计数及NLR、MLR、SIRI高于对照组(P<0.05)。观察组中,男性的WBC、NEUT、LYMPH、MONO计数及SIRI高于女性(P<0.05);对照组中,男性的MONO计数高于女性(P<0.05)。男性群体中,观察组的NEUT、MONO计数及NLR、MLR、SIRI高于对照组,LYMPH计数低于对照组(P<0.05);女性群体中,观察组的WBC、LYMPH计数低于对照组,MONO计数及NLR、MLR、SIRI高于对照组(P<0.05)。NLR、MLR、SIRI预测总体、男性、女性IBV感染的曲线下面积(AUC)均大于0.85,MLR的AUC、灵敏度、特异度均高于NLR与SIRI。结论 血常规衍生物NLR、MLR和SIRI在乙型流感患者早期筛查诊断中均有较高的应用价值。Objective To investigate the diagnostic value of blood routine derivatives neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR)and systemic inflammatory response index(SIRI)in patients with positive primary screening for influenza B virus(IBV)in outpatient and emergency department.Methods A retrospective collection of 188 patients with positive IBV screening who were admitted in the outpatient and emergency department of our hospital in January 2024 was included in the observation group,and 200 health people who underwent physical examination in our hospital during the same period were selected as the control group.The white blood cell(WBC),neutrophil(NEUT),lymphocyte(LYMPH)and monocyte(MONO)counts,NLR,MLR and SIRI were compared between the two groups and different genders;the receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of blood routine derivatives on IBV infection in different genders.Results The WBC and LYMPH counts in the observation group were lower than those in the control group,and the NEUT,MONO counts,NLR,MLR and SIRI were higher than those in the control group(P<0.05).In the observation group,the WBC,NEUT,LYMPH,MONO counts and SIRI of males were higher than those of females(P<0.05).In the control group,the MONO count of males was higher than that of females(P<0.05).In the male group,the NEUT,MONO counts,NLR,MLR and SIRI in the observation group were higher than those in the control group,and the LYMPH count was lower than that in the control group(P<0.05);in the female group,the WBC and LYMPH counts in the observation group were lower than those in the control group,and the MONO count,NLR,MLR and SIRI were higher than those in the control group(P<0.05).The area under the curve(AUC)of NLR,MLR and SIRI in predicting overall, male and female IBV infection was greater than 0.85, and the AUC, sensitivity and specificity of MLR were higher than those of NLR and SIRI. Conclusion Blood routine derivatives NLR, MLR and SIRI have high application value i

关 键 词：乙型流感病毒 血常规 中性粒细胞与淋巴细胞比值 单核细胞与淋巴细胞比值 全身炎症反应指数 

分 类 号：R511.7[医药卫生—内科学]