可弯曲支气管镜肺泡灌洗辅助治疗重症肺炎支原体肺炎患儿的临床效果及对肺通气功能的影响  

Clinical effect of flexible bronchoscopy alveolar lavage in adjuvant treatment of children with severe Mycoplasma pneumoniae pneumonia and its influence on pulmonary ventilation function

作　　者：丁建娟 卞志操 DING Jianjuan;BIAN Zhicao(Pediatrics Department,Dongtai People's Hospital of Jiangsu Province,Dongtai 224200,China)

机构地区：[1]江苏省东台市人民医院儿科,江苏东台224200

出　　处：《临床医学研究与实践》2025年第6期65-68,共4页Clinical Research and Practice

基　　金：江苏医药职业学院2024年度校地协同创新研究立项项目(No.202490508)。

摘　　要：目的 探讨可弯曲支气管镜肺泡灌洗辅助治疗重症肺炎支原体肺炎患儿的临床效果及对肺通气功能的影响。方法 选择2023年7月至2024年6月东台市人民医院收治的80例重症肺炎支原体肺炎患儿作为研究对象,以随机数字表法将其分为对照组和观察组,各40例。对照组采用常规药物治疗,观察组在对照组基础上予以可弯曲支气管镜肺泡灌洗辅助治疗。比较两组的治疗效果。结果 观察组的治疗总有效率高于对照组(P<0.05)。观察组的退热、咳嗽减轻、肺啰音消失、CT病灶恢复时间均短于对照组(P<0.05)。治疗后,观察组的第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及最高呼气流量(PEF)均高于对照组(P<0.05)。治疗后,观察组的动脉血氧分压(PaO_(2))、氧合指数(OI)高于对照组,动脉血二氧化碳分压(PaCO_(2))低于对照组(P<0.05)。治疗后,观察组的超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于对照组(P<0.05)。结论 可弯曲支气管镜肺泡灌洗辅助治疗重症肺炎支原体肺炎患儿的疗效显著,可缩短临床症状消失时间,提升肺通气功能及减轻炎症因子水平,值得临床应用。Objective To investigate the clinical effect of flexible bronchoscopy alveolar lavage in the adjuvant treatment of children with severe Mycoplasma pneumoniae pneumonia and its influence on pulmonary ventilation function.Methods A total of 80 children with severe Mycoplasma pneumoniae pneumonia admitted in Dongtai People's Hospital from July 2023 to June 2024 were selected as the research objects,and the children were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with flexible bronchoscopy alveolar lavage on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The time of fever,cough relief,lung rale disappearance and CT lesion recovery in the observation group were shorter than those in the control group(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and peak expiratory flow(PEF)in the observation group were higher than those in the control group(P<0.05).After treatment,the partial pressure of oxygen(PaO_(2))and oxygenation index(OI)in the observation group were higher than those in the control group,and the partial pressure of carbon dioxide(PaCO_(2))was lower than that in the control group(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).Conclusion Flexible bronchoscopy alveolar lavage in adjuvant treatment of children with severe Mycoplasma pneumoniae pneumonia is effective,it can shorten the disappearance time of clinical symptoms,improve pulmonary ventilation function and reduce the level of inflammatory factors,which is worthy of clinical application.

关 键 词：可弯曲支气管镜 肺泡灌洗 重症肺炎支原体肺炎 肺通气功能 炎症反应 

分 类 号：R563.1[医药卫生—呼吸系统]