四君子汤有效成分治疗胃癌的作用机制及临床应用研究进展  

Research progress on the mechanism and clinical application of the effective ingredients from Sijunzi decoction in the treatment of gastric cancer

作　　者：张红伟 党文飞 索欣 张茹 张岩 靳子明 窦霞 ZHANG Hongwei;DANG Wenfei;SUO Xin;ZHANG Ru;ZHANG Yan;JIN Ziming;DOU Xia(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Pharmaceutical Preparation Center,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China)

机构地区：[1]甘肃中医药大学药学院,兰州730000 [2]甘肃中医药大学附属医院制剂中心,兰州730020

出　　处：《中国药房》2025年第5期624-629,共6页China Pharmacy

基　　金：国家自然科学基金项目(No.82360944);甘肃省自然科学基金项目(No.25JRRA239);甘肃省中医药科研课题(No.GZKP-2022-23);兰州市科技计划项目(No.2022-5-109)。

摘　　要：胃癌是一种常见的消化道恶性肿瘤,其在中医学中可归为“痞满”“胃脘痛”“嘈杂”等范畴。四君子汤由人参、茯苓、白术及炙甘草组成,具有益气健脾的功效。本文归纳了四君子汤有效成分、治疗胃癌作用机制及临床应用的研究进展,结果发现,四君子汤主要有效成分有人参皂苷、白术内酯、茯苓酸、甘草酸等;四君子汤及其有效成分可通过抑制胃癌细胞增殖、促进胃癌细胞凋亡、增强胃癌细胞化疗敏感性及抑制胃癌细胞侵袭和转移发挥抗胃癌的作用;另外,四君子汤在临床治疗胃癌时可提高化疗药物疗效、增强机体免疫功能以及降低血清肿瘤标志物水平。Gastric cancer is a common malignant tumor of the digestive tract and can be classified as“fullness of the stomach”,“epigastric pain”,“noise”and other categories in the field of traditional Chinese medicine.Sijunzi decoction is composed of Panax ginseng,Poria cocos,Atractylodes macrocephala,and honey-fried Glycyrrhiza uralensis,and it has the effect of tonifying qi and strengthening the spleen.This article summarizes the active ingredients,mechanism of action,and clinical application research progress of Sijunzi decoction in treating gastric cancer.The results show that the main active ingredients of Sijunzi decoction include ginsenosides,atractylenolide,pachymic acid,glycyrrhizic acid,etc.;Sijunzi decoction and its effective ingredients can play an anti-gastric cancer role by inhibiting the proliferation of gastric cancer cell,inducing apoptosis of gastric cancer cell,enhancing gastric cancer cell chemotherapy sensitivity,and inhibiting invasion and metastasis of gastric cancer cell.In addition,Sijunzi decoction can enhance the efficacy of chemotherapy drugs,strengthen the immune function of the body and lower serum cancer marker levels during the clinical treatment of gastric cancer.

关 键 词：四君子汤 有效成分 胃癌 作用机制 临床疗效 

分 类 号：R965[医药卫生—药理学]