泊洛沙姆在新型制剂技术中的应用进展  

Progress in the application of poloxamer in new preparation technology

作　　者：齐雪 程艺 刘楠 王增明 张慧 郑爱萍 康东周[1] QI Xue;CHENG Yi;LIU Nan;WANG Zengming;ZHANG Hui;ZHENG Aiping;KANG Dongzhou(College of Pharmacy,Yanbian University,Jilin Yanji 133002,China;National Key Laboratory for Special Medicines Required for National Security,Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]延边大学药学院,吉林延吉133002 [2]军事医学研究院国家安全特需药品全国重点实验室,北京100850

出　　处：《中国药房》2025年第5期630-635,共6页China Pharmacy

基　　金：国家重点研发计划课题(No.2023YFC2706102)。

摘　　要：泊洛沙姆作为非离子表面活性剂,其独特的三嵌段(聚氧乙烯-聚环氧丙烷-聚氧乙烯)结构特性使其在固体分散体技术、纳米技术、凝胶技术、生物制剂技术、基因工程以及3D打印技术中均展现出广泛的应用潜力。作为载体,其提高了难溶性药物的溶解度和生物利用度;在纳米领域,其作为稳定剂等丰富了制备手段;在凝胶技术中,其自组装行为和温敏性有助于药物控释;在生物制剂中,其提升了靶向效率,减少了副作用;在基因工程中,其提高了传递效率和表达水平;在3D打印中,其为精确控制药物释放和制造高质量生物产品提供了新策略。作为一种多功能的材料,泊洛沙姆在医药领域中的应用前景广阔。Poloxamer,as a non-ionic surfactant,exhibits a unique triblock[polyethylene oxide-poly(propylene oxide)-polyethylene oxide]structure,which endows it with broad application potential in various fields,including solid dispersion technology,nanotechnology,gel technology,biologics,gene engineering and 3D printing.As a carrier,it enhances the solubility and bioavailability of poorly soluble drugs.In the field of nanotechnology,it serves as a stabilizer etc.,enriching preparation methods.In gel technology,its self-assembly behavior and thermosensitive properties facilitate controlled drug release.In biologics,it improves targeting efficiency and reduces side effects.In gene engineering,it enhances delivery efficiency and expression levels.In 3D printing,it provides novel strategies for precise drug release control and the production of high-quality biological products.As a versatile material,poloxamer holds promising prospects in the pharmaceutical field.

关 键 词：泊洛沙姆 制剂技术 三嵌段结构 载体 固体分散体 纳米技术 温敏凝胶 生物制剂 基因工程 3D打印 

分 类 号：R943[医药卫生—药剂学]