抗耐甲氧西林金黄色葡萄球菌抗菌肽的研究进展  

Research progress on antimicrobial peptides against methicillin-resistant Staphylococcus aureus

作　　者：王昱璇 郭伟昌[2] 陈诚 罗瑶[1] 肖亚雄[4] 李江涛[5] WANG Yuxuan;GUO Weichang;CHEN Cheng;LUO Yao;XIAO Yaxiong;LI Jiangtao(Department of Medical Affairs,the First People’s Hospital of Yibin,Sichuan Yibin 644000,China;Dept.of Vascular Surgery,the First People’s Hospital of Yibin,Sichuan Yibin 644000,China;Dept.of Pharmacy,the First People’s Hospital of Yibin,Sichuan Yibin 644000,China;Central Laboratory,the First People’s Hospital of Yibin,Sichuan Yibin 644000,China;Dept.of Rheumatology and Immunology,the First People’s Hospital of Yibin,Sichuan Yibin 644000,China)

机构地区：[1]宜宾市第一人民医院医务科,四川宜宾644000 [2]宜宾市第一人民医院血管外科,四川宜宾644000 [3]宜宾市第一人民医院药学部,四川宜宾644000 [4]宜宾市第一人民医院中心实验室,四川宜宾644000 [5]宜宾市第一人民医院风湿免疫科,四川宜宾644000

出　　处：《中国药房》2025年第5期636-640,共5页China Pharmacy

基　　金：四川省医学科研课题(No.S23039)。

摘　　要：金黄色葡萄球菌是一种具有较强致病力的革兰氏阳性菌,随着抗菌药物的广泛使用,其多重耐药性逐渐提高,其中耐甲氧西林金黄色葡萄球菌(MRSA)已成为院内和社区感染的重要病原菌之一。抗菌肽是一种短肽,具有抗菌效果好、不易产生耐药性等优势,近年来得到广泛研究。本研究通过对抗菌肽的作用机制及不同来源抗MRSA抗菌肽的相关研究进行总结,发现抗菌肽的作用机制包括作用于细菌细胞膜、细胞内和细胞壁等。除在动物、植物、微生物中分离得到抗MRSA感染的抗菌肽外,还可通过人工合成得到抗菌肽。其中动物来源的GHa衍生肽、植物来源的Ib-AMP4、微生物来源的Ph-SA、人工合成的抗菌肽LLKLLLKLL-NH2等,因其抗菌效果好、杀菌速度快、毒性低,均有望成为抗MRSA感染的候选药物。Staphylococcus aureus is a Gram-positive bacterium with strong pathogenicity.With the widespread use of antibiotics,its multi-drug resistance has gradually increased.Among them,methicillin-resistant S.aureus(MRSA)is one of the main pathogens of hospital and community infections.Antimicrobial peptides are short-chain peptides with good antibacterial effects and low drug resistance,which have been widely studied in recent years.This study summarizes the mechanism of action of antimicrobial peptides and related study on antimicrobial peptides against MRSA from different sources.It is found that the mechanisms of action of antimicrobial peptides include targeting bacterial cell membranes,bacterial cells,and bacterial cell walls,etc.Besides isolating antimicrobial peptides with anti-MRSA activity from animals,plants,and microorganisms,antimicrobial peptides can also be obtained through synthetic methods.Among them,GHa-derived peptides from animal sources,Ib-AMP4 from plant sources,Ph-SA from microbial sources,the synthetic peptide LLKLLLKLL-NH2,and so on,due to their effective antibacterial activity,rapid bactericidal speed,and low toxicity,are promising candidates for anti-MRSA drugs.

关 键 词：耐甲氧西林金黄色葡萄球菌 抗菌肽 作用机制 耐药性 

分 类 号：R965[医药卫生—药理学] TQ465.9[医药卫生—药学]