心房颤动相关认知功能障碍的药物治疗进展  

Advances in drug therapy for cognitive dysfunction associated with atrial fibrillation

作　　者：周璇[1] 饶莉[1] 张晓玲[1] ZHOU Xuan;RAO Li;ZHANG Xiaoling(Department of Cardiology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院心脏内科,成都610041

出　　处：《华西医学》2025年第2期313-317,共5页West China Medical Journal

基　　金：四川省科学技术厅自然科学基金(2024NSFSC1710)。

摘　　要：心房颤动(房颤)作为目前最常见的心律失常,可导致继发卒中后认知功能障碍,也可通过多种途径导致慢性脑损害,增加认知功能障碍的风险,从而影响患者预后。房颤相关认知功能障碍的预防及治疗药物主要包括抗凝药物、心律及心率控制药物、他汀类药物及降压药。目前对于房颤相关认知功能障碍的用药仍存在一定争议,缺乏指南推荐和专家共识,寻找安全经济且有效的相关药物来改善房颤患者的认知功能十分迫切且必要。该文通过对近年来房颤相关认知功能障碍的药物治疗进展进行总结归纳,以期为临床上房颤相关认知功能障碍的治疗提供参考。Atrial fibrillation,as the most common arrhythmia currently,can lead to secondary post-stroke cognitive dysfunction and chronic brain damage through various pathways,increasing the risk of cognitive dysfunction and affecting patient prognosis.The prevention and treatment drugs for cognitive dysfunction associated with atrial fibrillation mainly include anticoagulants,heart rhythm and heart rate control drugs,statins,and antihypertensive drugs.At present,there is still some controversy over the medication for cognitive dysfunction associated with atrial fibrillation,lacking guidelines and expert consensus.It is urgent and necessary to find safe,economical,and effective drugs to improve the cognitive function of atrial fibrillation patients.This article summarizes the recent advances in drug therapy for cognitive dysfunction associated with atrial fibrillation,in order to provide a reference for the treatment of cognitive dysfunction associated with atrial fibrillation in clinical practice.

关 键 词：心房颤动 认知功能障碍 药物治疗 

分 类 号：R541.75[医药卫生—心血管疾病] R749.1[医药卫生—内科学]