基于细胞钙循环及自主神经功能平衡的耳针改善心力衰竭心脏功能机制研究的新思路  

New perspective to study the mechanism of auricular acupuncture in improving cardiac function in heart failure based on cellular calcium cycling and balance of autonomic nervous system

作　　者：赵春晓 张颖[1] 辛娟娟[1] 刘群 周晨 江天云 吴爽 张雯晰 喻晓春[1] 高俊虹[1] ZHAO Chunxiao;ZHANG Ying;XIN Juanjuan;LIU Qun;ZHOU Chen;JIANG Tianyun;WU Shuang;ZHANG Wenxi;YU Xiaochun;GAO Junhong(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院针灸研究所,北京100700

出　　处：《中华中医药杂志》2025年第1期279-283,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.82174520)。

摘　　要：心力衰竭是众多心血管疾病的晚期结局,基本病理体征是兴奋-收缩偶联介导的心脏收缩舒张功能障碍。交感神经的代偿性活动增强和钙循环障碍是心力衰竭病理改变的基础。耳甲腔内迷走神经分支的存在为耳针用于治疗心力衰竭提供了可能。文章提出围绕心肌细胞钙循环调节的关键环节和机制以及以自主神经平衡为基础的交感/副交感神经交互抑制进而探究耳针改善心力衰竭心脏功能的疗效和作用机制的新思路,以期为耳针应用于心力衰竭的治疗提供科学依据。Characterized with the impaired systolic/diastolic function mediated by excitation-contraction coupling and developed from late stage of various cardiovascular diseases,heart failure(HF) is the disease with top mortality.Increased compensatory sympathetic activity and impaired calcium cycling regulation underlie the pathological changes in HF.More interestingly,the concha area of human ear is known to be innervated by vagus nerve.These above findings suggest a possibility for using auricular acupuncture to treat HF effectively.This paper puts forward a new idea to explore the efficacy and mechanism of HF therapy with auricular acupuncture,surrounding cardiomyocyte calcium cycling regulation and the sympathetic/parasympathetic interaction inhibition based on autonomic nerve balance.Hopefully,the achievements of this study will be the scientific evidence to strongly support the application of auricular acupuncture in the treatment of HF in future.

关 键 词：耳针 心力衰竭 细胞钙循环 交感/副交感活动 

分 类 号：R246.1[医药卫生—针灸推拿学]