中药方剂干预糖尿病并发症研究进展与思考  

Research progress and thinking on the intervention of diabetic complications with traditional Chinese medicine prescriptions

作　　者：陈冲 邓思敏 古文婷 王淑美 汤丹 CHEN Chong;DENG Simin;GU Wenting;WANG Shumei;TANG Dan(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of National Administration of Traditional Chinese Medicine,Guangzhou 510006,China;Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province,Guangzhou 510006,China)

机构地区：[1]广东药科大学中药学院,广州510006 [2]国家中医药管理局中药数字化质量评价技术重点研究室,广州510006 [3]广东省中药质量工程技术研究中心,广州510006

出　　处：《中华中医药杂志》2025年第1期311-317,共7页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.82074137);广东省普通高校重点领域专项(No.2022ZDZX2032);广东省基础与应用基础研究基金(No.2022A1515220068)。

摘　　要：糖尿病会引发包括脑、肾、心、周围神经等多器官损伤,严重者有致残致死的风险。目前西医临床实践中专科药物缺乏,对症治疗存在诸多问题。文章首先对中药方剂治疗糖尿病代表性并发症及其机制进行综述,发现中药方剂可通过调节糖脂代谢紊乱、缓解氧化应激、抑制炎症反应等途径发挥作用。同时,本团队针对目前本领域药理研究中存在的与中医理论脱节的问题,以糖尿病并发症“毒邪损络”病机为例,提出了“内生毒邪”生物学基础的假说,并以“从毒论治”为指导,开展解毒类经典名方的相关基础研究,以期为糖尿病并发症的治疗提供理论基础及科学依据。Diabetes mellitus can cause multiple organ damage including brain,kidney,heart and peripheral nerve,and even have the risk of disability and death.At present,there is a lack of safe and effective chemical drugs for the treatment of diabetic complications in clinical practices,and there are many problems in symptomatic treatment.This review firstly summarized the representative studies of traditional Chinese medicine prescriptions for the treatment of diabetic complications,and it is found that traditional Chinese medicine can exhibit beneficial effects by regulating glucose and lipid metabolism disorders,alleviating oxidative stress,and inhibiting the inflammatory response.Meanwhile,considering most pharmacological researches in this field were not according to the theory of traditional Chinese medicine,taking the pathogenesis of diabetic complications ‘the injury of collaterals by toxins' as an example,this paper put forward the hypothesis of the biological basis of ‘endogenous toxin',and carried out various researches on classical traditional Chinese medicine prescriptions with detoxification effects,in order to provide theoretical basis and scientific data for the treatment of diabetic complications.

关 键 词：中药方剂 糖尿病并发症 毒邪损络 内生毒邪 从毒论治 

分 类 号：R259[医药卫生—中西医结合]