血清sdLDL及Hcy和冠心病合并高脂血症患者冠脉病变程度的相关分析  

Correlation analysis between serum sdLDL and Hcy and the degree of coronary artery disease in patients with coronary heart disease and hyperlipidemia

作　　者：西热娜依 Xirenayi(Bozhou People’s Hospital,Bozhou,Xinjiang 833400,China)

机构地区：[1]新疆博州人民医院,新疆博州833400

出　　处：《首都食品与医药》2025年第4期49-51,共3页Capital Food Medicine

摘　　要：目的分析血清小而密低密度脂蛋白(sdLDL)及同型半胱氨酸(Hcy)和冠心病(CHD)合并高脂血症(HPL)患者冠脉病变程度的相关性。方法选取本院2023年6月-2024年6月诊治的50例CHD合并HPL患者(CHD-HPL组)、50例CHD患者(CHD组)、50例健康体检者(对照组)纳入研究,三组均行血清sdLDL及Hcy检测,比较其差异。参照Gensini评分标准进行冠脉病变程度评估,将CHD-HPL组患者分为轻度组(12例)、中度组(23例)、重度组(10例)、极重度组(5例),比较四组的血清sdLDL及Hcy检测结果。运用Pearson相关性分析法,分析血清sdLDL、Hcy与Gensini评分的相关性。结果CHD-HPL组、CHD组、对照组的血清sdLDL及Hcy比较,差异显著,P<0.05;CHD-HPL组的血清sdLDL及Hcy高于CHD组、对照组,P<0.05;CHD组的血清sdLDL及Hcy高于对照组,P<0.05。轻度组、中度组、重度组、极重度组的血清sdLDL及Hcy比较,差异显著,P<0.05;极重度组的血清sdLDL及Hcy高于轻度组、中度组、重度组,P<0.05;重度组的血清sdLDL及Hcy高于轻度组、中度组,P<0.05;中度组的血清sdLDL及Hcy高于轻度组,P<0.05。Pearson分析结果显示,血清sdLDL、Hcy与Gensini评分均呈明显的正相关性(P<0.05)。结论血清sdLDL及Hcy在CHD合并HPL患者中呈异常升高状态,且与冠脉病变程度存在一定的相关性,可作为患者病情及严重程度评估的参考指标。Objective To analyze the correlation between serum small and dense low-density lipoprotein(sdLDL)and homocysteine(Hcy)levels and the degree of coronary artery disease(CHD)combined with hyperlipidemia(HPL)in patients with coronary heart disease(CHD).Methods 50 patients with CHD combined with HPL(CHD-HPL group),50 patients with CHD(CHD group),and 50 healthy individuals(control group)treated in our hospital from June 2023 to June 2024 were selected for the study.Serum sdLDL and Hcy were measured in all three groups,and the differences were compared.According to the Gensini scoring criteria,the degree of coronary artery disease was evaluated,and CHD-HPL patients were divided into mild group(12 cases),moderate group(23 cases),severe group(10 cases),and extremely severe group(5 cases).The serum sdLDL and Hcy test results of the four groups were compared.Using Pearson correlation analysis method,analyze the correlation between serum sdLDL,Hcy and Gensini score.Results The serum sdLDL and Hcy of the CHDHPL group,CHD group,and control group were compared,the difference was statistically significant,with P<0.05;the serum sdLDL and Hcy of the CHD-HPL group were higher than those of the CHD group and control group,with P<0.05;the serum sdLDL and Hcy of the CHD group were higher than those of the control group,with P<0.05.The serum sdLDL and Hcy of the mild,moderate,severe,and extremely severe groups were compared,with P<0.05;the serum sdLDL and Hcy of the extremely severe group were higher than those of the mild,moderate,and severe groups,with P<0.05;the serum sdLDL and Hcy of the severe group were higher than those of the mild and moderate groups,with P<0.05;and the serum sdLDL and Hcy of the moderate group were higher than those of the mild group,the difference was statistically significant,with P<0.05.Pearson analysis results showed that serum sdLDL,Hcy,and Gensini scores were significantly positively correlated(P<0.05).Conclusion Serum sdLDL and Hcy are abnormally elevated in patients with CHD combined with HPL,and have

关 键 词：sdLDL HCY 冠心病 高脂血症 冠脉病变程度 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]