咪达唑仑联合芬太尼在机械通气重症肺炎患儿中的镇痛效果观察  

Analgesic effect of midazolam combined with fentanyl in mechanically ventilated children with severe pneumonia

作　　者：胡勇 Hu Yong(Zhejiang Provincial People’s Hospital Bijie Hospital,Bijie,Guizhou 551700,China)

机构地区：[1]浙江省人民医院毕节医院,贵州毕节551700

出　　处：《首都食品与医药》2025年第1期61-63,共3页Capital Food Medicine

摘　　要：目的分析在机械通气重症肺炎患儿中应用咪达唑仑联合芬太尼镇痛的效果。方法对2023年1月-2024年6月我院80例机械通气重症肺炎患儿予以研究。遵循随机抽样法分组,A组(n=40)给予咪达唑仑单药镇静镇痛,B组(n=40)在A组基础上加用芬太尼,比较患儿血压、心率、镇静镇痛效果及机械通气时间、住院时间。结果比较不同时间段HR、SBP、DBP,用药前两组均无明显差异(P>0.05),用药后6h、24h,B组HR、SBP、DBP均低于A组,具有统计学差异(P<0.05)。用药前比较,两组Ramsay、FLACC评分无明显差异(P>0.05);用药后6h、24h比较,B组Ramsay评分高于A组、FLACC评分低于A组,具有统计学差异(P<0.05)。比较住院时间、机械通气时间,B组短于A组(P<0.05)。结论咪达唑仑联合芬太尼能稳定机械通气重症肺炎患儿的血流动力学,镇静镇痛效果好,值得借鉴与应用。Objective To explore the analgesic effect of midazolam combined with fentanyl in mechanically ventilated children with severe pneumonia.Methods Eighty children with mechanically ventilated severe pneumonia were studied,all of whom were admitted to hospital between January 2023 and June 2024.Group A(n=40)was given single-drug sedation and analgesia with midazolam,group B(n=40)was given fentanyl on the basis of group A.Blood pressure,heart rate,sedation and analgesia effect,mechanical ventilation time and hospital stay were compared.Results HR,SBP and DBP in different time periods were compared,and there were no differences between the two groups before medication(P>0.05),while the HR,SBP and DBP in group B were lower than those in group A at 6h and 24h after medication(P<0.05).Before medication,Ramsay and FLACC scores of the two groups were compared(P>0.05).After 6h and 24h,Ramsay score in group B was higher than that in group A,FLACC score was lower than that in group A,and there were differences between the two groups(P<0.05).The hospitalization time and mechanical ventilation time in group B were shorter than those in group A(P<0.05).Conclusion Midazolam combined with fentanyl can stabilize the hemodynamics of mechanically ventilated children with severe pneumonia,and has good sedative and analgesic effect,which is worthy of reference and application.

关 键 词：机械通气 重症肺炎 患儿 咪达唑仑 芬太尼 

分 类 号：R563.1[医药卫生—呼吸系统]