药师指导下予以保肝药对预防抗肿瘤药物肝损伤及用药合理性分析  

Under the guidance of pharmacists,administering liver protective drugs to prevent liver injury caused by anti-tumor drugs and analyzing the rationality of medication use

作　　者：阮锐宏 肖玉婵 Ruan Ruihong;Xiao Yuchan(Zhongshan People’s Hospital,Zhongshan,Guangdong 528400,China)

机构地区：[1]广东省中山市人民医院,广东中山528400

出　　处：《首都食品与医药》2025年第1期82-84,共3页Capital Food Medicine

摘　　要：目的评估药师指导下予以保肝药对于预防抗肿瘤药物肝损伤的效果及对用药合理性的影响。方法纳入2023年1月-2024年1月中山市人民医院接受抗肿瘤药物治疗的74例患者,遵循随机数表法分组,即:对照组(纳入37例,未经药师指导使用保肝药)、观察组(纳入37例,药师指导下予以保肝药),评价组间药物性肝损伤(DILI)发生率、不合理用药情况。结果①与对照组DILI发生率(27.03%)相比,观察组(5.41%)更低,P<0.05;②与对照组不合理用药率(10.81%)相比,观察组(0.00%)更低,P<0.05。结论在药师指导下对接受抗肿瘤药物治疗的患者予以保肝药,可以提高保肝药用药合理性,有效预防肝损伤,有临床借鉴意义。Objective To evaluate the effectiveness of liver protective drugs administered under the guidance of pharmacists in preventing liver injury caused by anti-tumor drugs and their impact on the rationality of medication.Methods A total of 74 patients who received anti-tumor drug treatment at Zhongshan People’s Hospital from January 2023 to January 2024 were included in the study.They were randomly divided into a control group(37 patients were included,and liver protective drugs were used without the guidance of a pharmacist)and an observation group(37 patients were included,and liver protective drugs were given under the guidance of a pharmacist).The incidence of drug-induced liver injury(DILI)and irrational drug use among the groups were evaluated.Results①Compared with the control group(27.03%),the incidence of DILI in the observation group(5.41%)was lower,P<0.05;②Compared with the control group(10.81%),the incidence of irrational drug use in the observation group(0.00%)was lower,P<0.05.Conclusion Under the guidance of pharmacists,administering liver protective drugs to patients receiving anti-tumor drug treatment can improve the rationality of liver protective drug use,effectively prevent liver injury,and have clinical reference significance.

关 键 词：药师 指导 保肝药 抗肿瘤药物 肝损伤 用药合理性 

分 类 号：R969.3[医药卫生—药理学]