ESR、NLR、PLR、HLR、HPR、LMR联合检测在诊断类风湿性关节炎及评估其病情活动中的临床价值  

The clinical value of combined detection of ESR,NLR,PLR,HLR,HPR,and LMR in diagnosing rheumatoid arthritis and evaluating its disease activity

作　　者：梁晓华 李慧 邹湘玮 Liang Xiaohua;Li Hui;Zou Xiangwei(The Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong 510630,China;Zhongliu Biomedical Innovation Research Institute in Huangpu District,Guangzhou,Guangdong 510630,China)

机构地区：[1]中山大学附属第六医院,广东广州510630 [2]广州市黄埔区中六生物医学创新研究院,广东广州510630

出　　处：《首都食品与医药》2025年第1期90-93,共4页Capital Food Medicine

摘　　要：目的探究红细胞沉降率(ESR)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、血红蛋白与淋巴细胞比值(HLR)、血红蛋白与血小板比值(HPR)、淋巴细胞与单核细胞比值(LMR)联合检测在诊断类风湿性关节炎(RA)及评估其病情活动中的应用价值。方法收集2023年1月-2024年1月中山大学附属第六医院收治的88例RA患者的临床资料作为RA组,另收集同期于中山大学附属第六医院体检的102例健康人群资料作为健康组,开展回顾性分析,比较两组ESR、NLR、PLR、HLR、HPR、LMR表达水平。分析ESR、NLR、PLR、HLR、HPR、LMR联合检测在诊断类风湿性关节炎及评估其病情活动中的应用价值。结果RA组ESR、NLR、PLR、LMR均高于健康组,HPR、HLR均低于健康组(P<0.05);活动期ESR、LMR均高于缓解期,HLR、HPR均低于缓解期(P<0.05);构建Logistic多元回归模型发现,ESR升高和HLR降低是RA患者病情活动的关系的风险因子(P<0.05);绘制ROC曲线,ESR联合HLR检测在评估RA病情活动时,AUC=0.825(95%CI:0.739-0.911)。结论ESR联合HLR检测在评估RA病情活动时具有良好的预测价值。Objective To explore the application value of the combination of erythrocyte sedimentation rate(ESR),neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),hemoglobin to lymphocyte ratio(HLR),hemoglobin to platelet ratio(HPR),and lymphocyte to monocyte ratio(LMR)in the diagnosis of rheumatoid arthritis(RA)and evaluation of its disease activity.Methods Clinical data of 88 RA patients admitted to the Sixth Affiliated Hospital of Sun Yat-sen University from January 2023 to January 2024 were collected as the RA group.In addition,data of 102 healthy individuals who underwent physical examinations at the Sixth Affiliated Hospital of Sun Yat-sen University during the same period were collected as the healthy group.Retrospective analysis was conducted to compare the expression levels of ESR,NLR,PLR,HLR,HPR,and LMR between the two groups.Analyze the application value of combined detection of ESR,NLR,PLR,HLR,HPR,and LMR in the diagnosis of rheumatoid arthritis and evaluation of its disease activity.Results ESR,NLR,PLR and LMR in the RA group were higher than those in the healthy group,while HPR and HLR were lower than those in the healthy group(P<0.05);ESR and LMR during the active period were higher than those during the remission period,while the HLR,HPR were lower than those during the remission period(P<0.05);constructing a Logistic multiple regression model,it was found that an increase in ESR and a decrease in HLR are risk factors for the relationship between disease activity in RA patients(P<0.05);draw ROC curve and combine ESR with HLR detection to evaluate RA disease activity,AUC=0.825(95%CI:0.739-0.911).Conclusion ESR combined with HLR detection has good predictive value in evaluating RA disease activity.

关 键 词：类风湿性关节炎 红细胞沉降率 中性粒细胞 血红蛋白与淋巴细胞比值 

分 类 号：R446.1[医药卫生—诊断学]