2型糖尿病患者肾功能检查中应用β2-微球蛋白、尿素氮、血肌酐、胱抑素C与糖化血红蛋白联合检测对诊断准确率的影响  

Effect of combined detection ofβ2-microglobulin,urea nitrogen,creatinine,cystatin C and glycated hemoglobin on diagnostic accuracy of renal function in patients with type 2 diabetes

作　　者：章双虎 张丹 Zhang Shuanghu;Zhang Dan(Maqiao Community Health Service Center,Minhang District,Shanghai 201111,China)

机构地区：[1]上海市闵行区马桥社区卫生服务中心,上海201111

出　　处：《首都食品与医药》2025年第1期93-96,共4页Capital Food Medicine

摘　　要：目的分析2型糖尿病患者肾功能检查中实施β2-微球蛋白、尿素氮、血肌酐、胱抑素C与糖化血红蛋白联合检测的效果。方法选择在本院2022年1月-2024年2月期间接受肾功能和糖化血红蛋白检验的80例受检者,30例健康体检者为对照组,25例2型糖尿病肾损伤患者为观察A组,25例单纯2型糖尿病患者作为观察B组,分析三组的肾功能指标与糖化血红蛋白数值。结果和对照组相比,观察A组、B组的β2-微球蛋白、尿素氮、血肌酐和胱抑素C均更高,其中观察A组的β2-微球蛋白、尿素氮、血肌酐及其胱抑素C指标明显高于观察B组,对比具有统计学差异(P<0.05),观察A组、B组的糖化血红蛋白水平更高于对照组,对比具有统计学差异(P<0.05)。在糖尿病相关检测指标的ROC曲线分析中,联合检测的SE为0.04,AUC(曲线下面积)为0.807,95%CI在0.738-0.864(P<0.05)。结论β2-微球蛋白、尿素氮、血肌酐、胱抑素C和糖化血红蛋白联合检测的方式有利于医师观察2型糖尿病患者病情发展状态,为针对性治疗、判断预后恢复效果提供可靠依据,敏感度高,值得在临床上推广。Objective To analyze the effect of combined detection of β2-microglobulin,urea nitrogen,creatinine,cystatin C and glycated hemoglobin in renal function in patients with type 2 diabetes.Methods From January 2022 to February 2024,80 patients were selected in our hospital,30 healthy subjects were selected as control group,25 patients with type 2 diabetes kidney injury were selected as observation group A,and 25 patients with simple type 2 diabetes were selected as observation group B.The renal function indexes and HBA1c values of the three groups were analyzed.Results Compared with the control group,the levels of β2-microglobulin,urea nitrogen,serum creatinine and cystatin C in observation groups A and B were higher,and the levels of β2-microglobulin,urea nitrogen,serum creatinine and cystatin C in observation group A were significantly higher than those in observation group B,with statistical significance(P<0.05);the levels of glycosylated hemoglobin in observation groups A and B were higher than those in control group,the comparison was statistically significant(P<0.05).In ROC curve analysis of diabetes-related test indicators,SE was 0.04,AUC(area under the curve)was 0.807,and 95%CI were 0.738-0.864(P<0.05).Conclusion The combination test of β2-microglobulin,urea nitrogen,serum creatinine,cystatin C and glycated hemoglobin is beneficial for physicians to observe the development of type 2 diabetes patients,and provides a reliable basis for targeted treatment and judgment of prognosis and recovery effect.It is highly sensitive and worthy of clinical recommendation.

关 键 词：2型糖尿病 肾功能 糖化血红蛋白 检验 

分 类 号：R446.1[医药卫生—诊断学]