盐酸利托君联合地屈孕酮治疗先兆早产的临床有效性及母婴结局评估  

Clinical Efficacy and Maternal and Infant Outcomes Evaluation of the Combination of Ritodrine Hydrochloride and Dydrogesterone in the Treatment of Preterm Labor

作　　者：蔡雅瑜 蔡雅萍 李文君 CAI Yayu;CAI Yaping;LI Wenjun(Department of Obstetrics and Gynecology,Jinjiang Traditional Chinese Medicine Hospital,Jinjiang,Fujian,362200,China)

机构地区：[1]晋江市中医院妇产科,福建晋江362200

出　　处：《中外医疗》2024年第36期123-127,共5页China & Foreign Medical Treatment

摘　　要：目的分析先兆早产使用盐酸利托君联合地屈孕酮疗效。方法随机选取2021年1月—2023年12月晋江市中医院收治的100例先兆早产患者为研究对象,根据治疗方案差异分为对照组(50例,单独使用盐酸利托君治疗)与观察组(50例,盐酸利托君联合地屈孕酮)。对比两组母婴结局、临床相关指标、临床疗效、实验室指标、不良反应发生情况。结果临床总有效率比较,观察组为96.00%(48/50),高于对照组的82.00%(41/50),差异有统计学意义(χ^(2)=5.005,P<0.05)。治疗后,观察组白细胞介素-10水平高于对照组,前列腺素E2水平低于对照组,宫缩消失时间短于对照组,妊娠延长天数长于对照组,新生儿Apgar评分、新生儿体重均高于对照组、宫缩频次低于对照组、宫颈管长度大于对照组,差异均有统计学意义(P均<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论应用盐酸利托君联合地屈孕酮治疗先兆早产具有较好的临床疗效,可改善母婴结局及临床相关指标,联合用药未增加不良反应,安全性良好。Objective To analyze the efficacy of ritodrine hydrochloride combined with dydrogesterone in the treatment of threatened premature labor.Methods A total of 100 patients with preterm labor admitted to Jinjiang Traditional Chinese Medicine hospital from January 2021 to December 2023 were randomly selected as the research objects.According to the differences in treatment regimens,they were divided into the control group(50 cases,treated with ritodrine hydrochloride alone)and the observation group(50 cases,treated with ritodrine hydrochloride combined with dydrogesterone).The clinical efficacy,maternal and infant outcomes,laboratory indicators,clinical related indicators,and adverse reactions were compared between the two groups.Results The total clinical efficacy of the observation group was 96.00%(48/50),which was higher than that of the control group 82.00%(41/50),and the difference was statistically significant(χ^(2)=5.005,P<0.05).After treatment,the level of interleukin-10 in the observation group was higher than that in the control group,the level of prostaglandin E2 was lower than that in the control group,the time for uterine contraction to disappear was shorter than that in the control group,the number of days of pregnancy prolongation was longer than that in the control group,the neonatal Apgar score and neonatal body weight were higher than those in the control group,the frequency of uterine contractions was lower than that in the control group,and the length of the cervical canal was greater than that in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of ritodrine hydrochloride combined with dydrogesterone in the treatment of preterm labor has a good clinical effect,which can improve maternal and infant outcomes and clinical related indicators.The combination does not increase adverse reactions and has good safety.

关 键 词：先兆早产 地屈孕酮 盐酸利托君 临床疗效 母婴结局 

分 类 号：R714[医药卫生—妇产科学]