沙库巴曲缬沙坦结合美托洛尔急诊治疗老年重症心力衰竭患者的疗效研究  

Efficacy Study of Sacubitril Valsartan Combined with Metoprolol in the Emergency Treatment of Elderly Patients with Severe Heart Failure

作　　者：黄振军 梁思雅 洪清雅 HUANG Zhenjun;LIANG Siya;HONG Qingya(Nan'an Hospital,Nan'an,Fujian,362300,China)

机构地区：[1]南安市医院,福建南安362300

出　　处：《中外医疗》2024年第36期141-144,149,共5页China & Foreign Medical Treatment

摘　　要：目的以老年重症心力衰竭患者为例,分析应用沙库巴曲缬沙坦结合美托洛尔在急诊治疗中的效果。方法方便选取2022年1月—2023年12月南安市医院急诊收治的82例老年重症心力衰竭患者作为研究对象,患者按治疗方案分为对照组(美托洛尔治疗)和观察组(沙库巴曲缬沙坦联合美托洛尔治疗),每组41例,将二者临床疗效、临床相关指标、心功能情况、不良反应情况实施对照分析。结果相比于对照组的80.49%(33/41),观察组的临床治疗总有效率97.56%(40/41)更高,差异有统计学意义(χ^(2)=4.493,P<0.05)。治疗后,两组患者的体循环阻力与B型脑利钠肽水平均低于治疗前,一氧化氮与6 min步行测试结果均高于治疗前,且观察组患者的一氧化氮、6min步行测试均高于对照组,体循环阻力与B型脑利钠肽结果均低于对照组,差异均有统计学意义(P均<0.05)。治疗后,两组患者的心功能指标均优于治疗前,且观察组优于对照组,差异均有统计学意义(P均<0.05)。两组患者的不良反应发生率对比,差异无统计学意义(P>0.05)。结论从临床治疗的角度,沙库巴曲缬沙坦结合美托洛尔用于老年重症心力衰竭患者,可提高治疗效果并保障治疗安全。Objective To analyze the effect of sacubitril valsartan combined with metoprolol in the emergency treatment of elderly patients with severe heart failure.Methods A total of 82 elderly patients with severe heart failure admitted to the emergency department of Nan'an Hospital from January 2022 to December 2023 were conveniently selected as the research subjects.The patients were divided into control group(metoprolol treatment)and observation group(sacubitril valsartan combined with metoprolol treatment)according to the treatment plan,with 41 cases in each group.The clinical efficacy,clinical related indicators,cardiac function,and adverse reactions of the two groups were analyzed comparatively.Results The total effective rate of clinical treatment in the observation group was 97.56%(40/41),which was higher than 80.49%(33/41)in the control group,and the difference was statistically significant(χ^(2)=4.493,P<0.05).After treatment,the systemic circulation resistance and B-type natriuretic peptide(BNP)levels of both groups were lower than those before treatment,while the nitric oxide(NO)levels and the results of the 6 min walk test were higher than those before treatment,the NO levels and the results of the 6 min walk test in the observation group were higher than those in the control group,and the systemic circulation resistance and BNP levels were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the cardiac function indicators of both groups were better than those before treatment,and the observation group were better than those of the control group,and the differences were statistically significant(both P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion From the perspective of clinical treatment,sacubitril valsartan combined with metoprolol in elderly patients with severe heart failure can improve the therapeutic effect and ensure the safety of treatment.

关 键 词：急诊 沙库巴曲缬沙坦 美托洛尔 老年 重症心力衰竭 临床疗效 

分 类 号：R5[医药卫生—内科学]