醒脾养儿颗粒治疗小儿原发性夜间遗尿症的临床分析  

Clinical Analysis of Xingpi Yang'er Granules in the Treatment of Primary Nocturnal Enuresis in Children

作　　者：张美红 王璐 庄宇 ZHANG Meihong;WANG Lu;ZHUANG Yu(Department of Nephrology,Children's Specialized Branch,Fuzhou First General Hospital,Fuzhou,Fujian,350001,China)

机构地区：[1]福建省福州第一总医院儿童专科院区肾内科,福建福州350001

出　　处：《中外医疗》2024年第36期186-189,194,共5页China & Foreign Medical Treatment

摘　　要：目的探究原发性夜间遗尿症患儿应用醒脾养儿颗粒的作用。方法方便选取2022年1月—2023年12月福建省福州第一总医院儿童专科院区收治的92例原发性夜间遗尿症患儿作为研究对象,根据不同治疗方法分为中医联合组(n=46)、常规组(n=46)。常规组给予基础治疗方案,中医联合组在此基础上加用醒脾养儿颗粒。比较两组的治疗效果、临床相关指标、血清因子指标、不良反应发生情况及复发情况。结果中医联合组治疗总有效率优于常规组,差异有统计学意义(P<0.05)。治疗前,两组患儿相关临床指标比较,差异无统计学意义(P>0.05)。治疗后,中医联合组患儿的遗尿频率及膀胱容量壁厚指数(bladder capacity wall thicknessindex,BVWI)分别为(1.35±0.40)次/周与(44.05±12.37)mL/mm,均低于常规组的(3.07±0.53)次/周与(58.87±12.95)mL/mm,膀胱容量为(289.42±18.66)mL,高于常规组的(237.58±21.45)mL,差异均有统计学意义(t=17.569,5.613,12.367;P均<0.05)。治疗前,两组血清因子指标比较,差异无统计学意义(P>0.05)。治疗后,两组患儿的环磷酸腺苷与精氨酸加压素均高于治疗前,环磷酸鸟苷低于治疗前;且中医联合组患儿的环磷酸腺苷与精氨酸加压素均高于常规组,环磷酸鸟苷低于常规组,差异均有统计学意义(P均<0.05)。两组患儿不良反应发生情况比较,差异无统计学意义(P>0.05)。两组患儿治疗3个月复发情况比较,差异无统计学意义(P>0.05);中医联合组治疗6个月、12个月复发率均低于常规组,差异均有统计学意义(P均<0.05)。结论醒脾养儿颗粒能够提高原发性夜间遗尿症患儿的治疗效果,改善相关临床指标及血清因子指标,减少疾病复发,且安全性较好。Objective To explore the effect of Xingpi Yang'er Granules in children with primary nocturnal enuresis.Methods A total of 92 children with primary nocturnal enuresis admitted to the Children's Specialized Hospital Branch of Fuzhou First General Hospital of Fujian Province from January 2022 to December 2023 were conveniently selected as the research subjects.According to different treatment methods,they were divided into the traditional Chinese medicine(TCM)combination group(n=46)and the routine group(n=46).The routine group was given the basic treatment plan,and the TCM combination group was additionally administered with Xingpi Yang'er Granules on this basis.The treatment effects,clinical related indicators,serum factor indicators,occurrence of adverse reactions and recurrence situations of the two groups were compared.Results The total effective rate of the TCM combination group was better than that of the routine group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the relevant clinical indicators between the two groups of children(P>0.05).After treatment,the enuresis frequency and bladder capacity wall thickness index(BVWI)of the children in the TCM combination group were(1.35±0.40)time/week and(44.05±12.37)mL/mm respectively,which were lower than(3.07±0.53)time/week and(58.87±12.95)mL/mm of the routine group,and the bladder capacity was(289.42±18.66)mL,which was higher than(237.58±21.45)mL of the routine group,the differences were all statistically significant(t=17.569,5.613,12.367;all P<0.05).Before treatment,there was no statistically significant difference in the serum factor indicators between the two groups(P>0.05).After treatment,the cyclic adenosine monophosphate and arginine vasopressin of the two groups of children were higher than those before treatment,and the cyclic guanosine monophosphate was lower than that before treatment,moreover,the cAMP and AVP of the children in the TCM combination group were higher than

关 键 词：醒脾养儿颗粒 小儿原发性夜间遗尿症 治疗效果 临床相关指标 血清因子指标 不良反应发生情况 复发情况 

分 类 号：R72[医药卫生—儿科]