麻醉药物对体外循环下心脏手术PND影响的研究进展  

Research progress on the effect of anesthetics on PND in cardiac surgery under cardiopulmonary bypass

作　　者：陆俊 吕洁 蒋柯 史静 Lu Jun;Lyu Jie;Jiang Ke;Shi jing(Department of Anesthesiology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550001,China)

机构地区：[1]贵州医科大学附属医院麻醉科,贵阳550001

出　　处：《保健医学研究与实践》2024年第11期127-131,共5页Health Medicine Research and Practice

基　　金：贵州省科技厅基础研究计划(ZK[2023]一般-390);贵州省卫生健康委科学技术基金(gzwkj2024-173);贵阳市科技局项目([2022]-4-2-6)。

摘　　要：围术期神经认知障碍(PND)是体外循环(CPB)下心脏手术患者术后的一种严重并发症,其发生率可高达50%。虽然麻醉药是影响CPB下心脏手术患者PND的重要因素之一,但不同的麻醉药物对CPB下心脏手术患者PND的影响存在着显著差异。本文就临床常用的心血管麻醉药物对CPB下心脏手术患者PND的影响进行综述,并展望新型麻醉药物对防治CPB下心脏手术患者PND的可能应用前景,以期为CPB下心脏手术的麻醉用药提供一定的参考。Perioperative neurocognitive disorder(PND)is a serious complication after cardiac surgery in patients undergoing Cardiopulmonary Bypass(CPB).The incidence of PND in cardiac surgery patients can be as high as 50%.Although anesthetics are one of the important factors affecting PND in CPB cardiac surgery patients,the effects of different anesthetics on PND in CPB cardiac surgery patients are significantly different.This article reviews the effects of commonly used cardiovascular anesthesia drugs on PND in patients undergoing CPB cardiac surgery,and looks forward to the possible application prospects of new anesthesia drugs in the prevention and treatment of PND in patients undergoing cardiac surgery under CPB,in order to provide certain reference for anesthesia drugs in cardiac surgery under CPB.

关 键 词：围术期神经认知障碍 心脏手术 体外循环 静脉麻醉药 吸入麻醉药 

分 类 号：R971[医药卫生—药品]