上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展  

Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging

作　　者：海热古·吐逊 郭乐 丁嘉仪 周嘉琪 张学良[1] 努尔尼沙·阿力甫 HAIREGU Tuxun;GUO Le;DING Jiayi;ZHOU Jiaqi;ZHANG Xueliang;NUERNISHA Alifu(School of Medical Engineering and Technology,Xinjiang Medical University,Urumqi 830011,China;School of Public Health,Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学医学工程技术学院,乌鲁木齐830011 [2]新疆医科大学公共卫生学院,乌鲁木齐830011

出　　处：《无机材料学报》2025年第2期145-158,共14页Journal of Inorganic Materials

基　　金：新疆维吾尔自治区自然科学基金青年科学基金(2022D01C727);天池英才青年基金,省部共建中亚高发病成因与防治国家重点实验室面上项目(SKL-HIDCA-2023-15)。

摘　　要：肿瘤的早期诊断是癌症高效诊疗的关键基础。可视化荧光成像技术凭借其高时间-空间分辨率、高灵敏度、无电离辐射、无创和实时成像等优点,在生物医学领域尤其是肿瘤的早期诊断中展现出巨大应用潜力。与可见光相比,近红外(Near-infrared,NIR)光穿透生物组织时,其受到的吸收和散射显著减少,这一特性使得基于NIR光的荧光成像技术在生物医学领域展现出高信噪比及高空间分辨率的独特优势,而高质量NIR荧光成像依赖于性能卓越的荧光探针。在众多荧光探针中,NIR光激发的上转换纳米颗粒(Upconversion Nanoparticles,UCNPs)因其低毒性、窄带发射、可调发射、长荧光寿命、良好的光化学稳定性以及高量子产率等优异特性,在荧光成像领域脱颖而出。本文总结了上转换荧光探针的基本原理、合成方法、改性与修饰技术,重点阐述了稀土掺杂上转换荧光探针在几种典型成像模式及肿瘤多模态成像中的最新研究进展,并对进一步实现诊疗一体化的应用研究进行了展望。Early diagnosis of tumor is a key factor for efficient diagnosis and treatment of cancer.Fluorescence imaging technology,particularly utilizing near-infrared(NIR)light,has shown promising potential in the biomedical field,specifically in the early detection of cancer.NIR light has minimal absorption and scattering in biological tissues,allowing for high-quality imaging with high resolution and signal-to-noise ratio.Realization of high-quality NIR fluorescence imaging relies on excellent fluorescent probes.Upconversion nanoparticles(UCNPs),excited by NIR light,have soared in fluorescence imaging due to their favorable characteristics such as low toxicity,narrow-band emission,tunable emission,long fluorescence lifetime,good stability,and high quantum yield.This article summarizes the basic principles,synthesis methods,and modification/decoration techniques of upconversion fluorescent probes,mainly expounds on several typical imaging modes of rare earth doped upconversion fluorescent probes and their latest research progress in tumor visualization,and prospects the further application research on the integration of diagnosis and treatment.

关 键 词：近红外荧光成像 上转换纳米颗粒 上转换荧光探针 多模态成像 综述 

分 类 号：R318[医药卫生—生物医学工程]