广州市6起脊髓灰质炎疫苗衍生病毒的发现与调查  

Discovery and investigation of six polio vaccine derived viruses in Guangzhou City

作　　者：崔敏[1] 张春焕[1] 张薇[2] 刘隽[2] 李佳玲[2] 许建雄[1] 王文佶 贺晴[1] 倪莉红[1] 云雪霞[1] 郑焕英[2] CUI Min;ZHANG Chunhuan;ZHANG Wei;LIU Jun;LI Jialing;XU Jianxiong;WANG Wenji;HE Qing;NI Lihong;YUN Xuexia;ZHENG Huanying(Guangzhou Center for Disease Control and Prevention,Guangzhou,Guangdong 510440,China;Guangdong Provincial Center for Disease Control and Prevention,Guangzhou,Guangdong 511430,China)

机构地区：[1]广东省广州市疾病预防控制中心,广东广州510440 [2]广东省疾病预防控制中心,广东广州511430

出　　处：《公共卫生与预防医学》2025年第2期22-25,共4页Journal of Public Health and Preventive Medicine

基　　金：广东省医学科研基金项目(B2022156,A2022027)。

摘　　要：目的了解广州市2011-2024年脊髓灰质炎(脊灰)病毒的监测情况,以进一步加强脊灰监测,确保继续维持无脊灰状态。方法对广州市6起疫苗衍生脊髓灰质炎病毒(Vaccine-derived Poliovirus,VDPV)的发现与调查结果进行分析。结果广州市2011-2024年共报告VDPV事件6起,其中,5起事件来源于广州市猎德污水处理厂的污水样本检测,具体分型为Ⅰ型、Ⅲ型VDPV各1起,Ⅱ型VDPV 3起。1起手足口确诊病例为VDPV II型携带者。未报告脊髓灰质炎野病毒(Wild Poliovirus,WPV)、VDPV病例或循环的VDPV(Circulating VDPV,cVDPVs)病例。结论广州市在脊灰监测与防控方面保持了较高的警惕性和有效性。持续加强脊灰监测网络建设、优化疫苗接种策略、全面提高公众健康意识仍是当前维持无脊灰工作的重点。Objective To understand the surveillance situation of poliovirus in Guangzhou from 2011 to 2024,and to further strengthen polio surveillance and ensure the continued maintenance of a polio-free status.Methods An analysis was conducted on the discovery and investigation results of six cases of vaccine-derived poliovirus(VDPV)detected in Guangzhou.Results A total of 6 VDPV incidents were reported in Guangzhou from 2011 to June 2024,among which 5 incidents were from sewage sample testing in the Liede Sewage Treatment Plant in Guangzhou,all of which were confirmed as VDPV,with 1 for type I,1 for type II,and 3 for type III.In addition,one confirmed HFMD case was identified as a type VDPV II carrier.No presence of any wild poliovirus(WPV),VDPV cases,or circulating VDPV(cVDPV)was reported.Conclusion Guangzhou City has maintained a high level of vigilance and effectiveness in the monitoring and prevention of polio.Continuously strengthening the construction of the polio monitoring network,optimizing vaccination strategies,and comprehensively improving public health awareness are still the focus of the prevention and control work in the future.

关 键 词：脊髓灰质炎 疫苗衍生脊髓灰质炎病毒 调查处置 

分 类 号：R181[医药卫生—流行病学]