武汉地区1866例慢性胃炎幽门螺杆菌检测及分型分析  

Prevalence and typing of Helicobacter Pylori of 1866 cases of chronic gastritis in Wuhan

作　　者：张珣 廖雯斐 彭波 ZHANG Xun;LIAO Wenfei;PENG bo(Department of Gastroenterology,Wuhan Third Hospital,Wuhan,Hubei 430061,China;Department of Gastroenterology,Wuhan Sixth Hospital,Wuhan,Hubei 430015,China)

机构地区：[1]湖北省武汉市第三医院消化内科,湖北武汉430061 [2]湖北省武汉市第六医院消化内科,湖北武汉430015

出　　处：《公共卫生与预防医学》2025年第2期61-64,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的调查分析武汉地区慢性胃炎人群幽门螺杆菌(helicobacter pylori,Hp)感染状况及免疫学分型结果。方法选取2021年5月至2023年12月例武汉地区1866例慢性胃炎患者为研究对象,采用免疫印迹法检测血清中Hp抗体及分型,分析不同性别、年龄组患者的感染率和分型情况,以及Hp感染与慢性胃炎病情严重程度之间的相关性。结果1866例患者中,Hp的总检出率为65.38%(1220/1866),其中Ⅰ型感染率61.31%(748/1220)高于Ⅱ型38.69%(472/1220)(P<0.05);男性和女性总感染率差异无统计学意义(P>0.05),其中男性Ⅰ型感染率70.08%(431/615)高于Ⅱ型29.92%(184/615)(P<0.05),而女性两种类型的感染率差异无统计学意义(P>0.05);按不同年龄段分组分析:不同年龄段患者的Hp感染率随年龄增长而增高(x^(2)=64.687,P=0.000),18岁以下、31~40岁、41~50岁和51~60岁Ⅰ型感染率高于Ⅱ型(P<0.05),而18~30岁和≥60岁组Ⅰ型和Ⅱ型感染率比较差异无统计学意义(P>0.05);随着慢性胃炎病情严重程度增加,感染率与Ⅰ型占比均升高,且Ⅰ型占比均高于Ⅱ型(P<0.05)。结论武汉地区慢性胃炎患者中存在较高比例的Hp感染,Hp感染率随患者年龄增长而增高,与病情严重程度呈正相关,且具有一定的分型特征。Objective To investigate prevalence and immunological properties of Helicobacter pylori(Hp)infection among chronic gastritis population in Wuhan.Methods A total of 1866 patients with chronic gastritis in Wuhan were selected from May 2021 to December 2023,and Hp antibody and typing in serum were detected by immunoblotting to analyse the infection rate and typing of patients of different genders and age groups,as well as the correlation between Hp infection and the severity of chronic gastritis.Western blotting technique was utilized to detect the Hp antibodies and typing.The infection rates and subtypes were recorded in patients of different genders and ages.Then the correlation between Hp infection and the severity of chronic gastritis were discussed.Results The overall detection rate of Hp infection was 65.38%(1220/1866)in 1866 patients,and the prevalence rate of type I infection was higher than that of type II infection[61.31%(748/1220)vs 38.69%(472/1220),P<0.05].No statistical difference was reported in overall infection rate in terms of gender(P>0.05).In terms of gender,the rate of type I infection was higher than that of type II infection[70.08%(431/615)vs 29.92%(184/615),P<0.05],whereas the prevalence of the two types of infections demonstrated no statistical difference in female patients(P>0.05).In terms of age,the prevalence of Hp infection in patients increased with age(x^(2)=64.687,P=0.000).The infection rate of type I was higher than type II in the age groups of below 18,31-40,41-50 and 51-60 years old(P<0.05),and infection rates of type I and type II yielded no statistical difference in the age groups of 18-30 and≥60 years old(P>0.05).With the aggravation of chronic gastritis,the infection rate and percentage of type I infections increased,and the percentage of type I infections was higher than that of type II infections(P<0.05).Conclusion Patients with chronic gastritis in Wuhan suffer a high prevalence rate of Hp infection,and the rate of Hp infection increases with the age of the patients,is posi

关 键 词：慢性胃炎 幽门螺杆菌 检测 分型 

分 类 号：R181[医药卫生—流行病学]