肌肉因子Irisin:改善高血压血管功能的新靶点  

Muscle myokine irisin:a new target for improving vascular function in hypertension

作　　者：张径遂 杨坡 张跃耀 何恩鹏[2] ZHANG Jingsui;YANG Po;ZHANG Yueyao;HE En-peng(Faculty of Geography and Tourism,Xinjiang Normal University,Urumqi,Xinjiang 830054,China;Key Laboratory of Human Body Science,College of Physical Education,Xinjiang Normal University,Urumqi,Xinjiang 830054,China;School of Art and Physical Education,Hebei University of Media and Communication,Shi Jiazhuang,Hebei 051430,China)

机构地区：[1]新疆师范大学地理科学与旅游学院,新疆乌鲁木齐830054 [2]新疆师范大学体育学院运动人体科学重点实验室,新疆乌鲁木齐830054 [3]河北传媒学院艺术体育学院,河北石家庄051430

出　　处：《公共卫生与预防医学》2025年第2期110-115,共6页Journal of Public Health and Preventive Medicine

基　　金：新疆维吾尔自治区自然科学基金项目支持(2021D01A120);新疆师范大学优秀青年教师科研启动基金项目(XJNU202211)。

摘　　要：心血管疾病(cardiovascular disease,CVD)是世界各国最常见与最致命的非传染性疾病。而其中原发性高血压在全球非传染性疾病中占很大比例。鸢尾素(Irisin)于2012年被首次发现并命名,作为一种肌肉因子,其具有调节机体糖脂代谢作用。运动不仅能促进Irisin参与机体能量代谢,更被发现Irisin能够干预高血压疾病的发展进程,对高血压疾病的改善产生积极作用。因此,此文对Irisin与高血压疾病的相关性研究进行回顾,归纳出Irisin对高血压疾病的血管功能的影响机制,分析在运动干预下Irisin对血压的影响。Cardiovascular disease(CVD)is the most common and fatal non communicable disease in the world.Hypertension accounts for a large proportion of global non communicable diseases.Irisin was first discovered and named in 2012.As a muscle myokine,irisin has the function of regulating glucose and lipid metabolism.Exercise can promote irisin′participation in energy metabolism in the body.At the same time,it has been found that irisin can intervene in the development of hypertension and have a positive effect on the improvement of hypertension.Therefore,this paper reviews research on the relationship between irisin and hypertension,summarizes the mechanism of irisin′action on vascular function in hypertension,and analyzes the effect of irisin on blood pressure under exercise intervention.

关 键 词：Irisin 高血压 血管功能 运动 

分 类 号：R181[医药卫生—流行病学]