慢性肾脏疾病患者高磷血症与钙化防御的相关性研究进展  

Research progress on correlation between hyperphosphatemia and calciphylaxis in patients with chronic kidney disease

作　　者：杨莉 周莉 高雪 YANG Li;ZHOU Li;GAO Xue(Hemodialysis Room,Department of Nephrology,West China Hospital/West China Nursing College,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西医院肾脏内科血透室/四川大学华西护理学院,四川成都610041

出　　处：《公共卫生与预防医学》2025年第2期121-125,共5页Journal of Public Health and Preventive Medicine

基　　金：四川大学研究生教育教学改革研究项目(GSSCU2021136)。

摘　　要：高磷血症是晚期慢性肾脏疾病患者的常见并发症,为引起继发性甲状旁腺功能亢进、钙磷沉积变化、维生素D代谢障碍、肾性骨病的重要因素。钙化防御为临床上一种较为罕见且致死率极高的疾病,目前多认为可能与钙磷代谢异常有关。此文根据既往研究结果,汇总钙化防御与高磷血症的关系、发生机制,以及预防治疗手段,以期提高对该疾病的认知度及重视度。Hyperphosphatemia is a common complication in patients with advanced chronic kidney disease,which is an important factor causing secondary hyperparathyroidism,calcium-phosphorus deposition changes,vitamin D metabolism disorders and renal osteopathy.Calciphylaxis is a rare and highly fatal disease in clinical practice,which is generally believed to be related to abnormal calcium-phosphorus metabolism.Based on the results of previous studies,this paper summarizes the relationship between calciphylaxis and hyperphosphatemia,its occurrence mechanism,and prevention and treatment methods,in order to improve the awareness and attention of this disease.

关 键 词：慢性肾脏疾病 高磷血症 钙化防御 发病机制 

分 类 号：R181[医药卫生—流行病学]