嗜肺军团菌调控宿主细胞骨架的研究进展  

Advances on the regulation of host cytoskeleton by Legionella pneumophila

作　　者：方艺津 陈涛涛 欧阳松应 FANG YiJin;CHEN TaoTao;OUYANG SongYing(College of Life Sciences,Fujian Normal University,Fuzhou 350117,China)

机构地区：[1]福建师范大学生命科学学院,福州350117

出　　处：《中国科学:生命科学》2025年第2期313-324,共12页Scientia Sinica(Vitae)

基　　金：国家重点研发计划(批准号:2021YFC2301403);国家自然科学基金(批准号:82225028,82172287)资助。

摘　　要：宿主细胞利用抗菌蛋白、病原体限制性区隔化和细胞死亡等策略来防御胞内病原体.近年来大量的研究表明,细胞骨架的主要组成成分——微丝、微管、中间丝以及隔膜,在维持细胞形态结构、细胞运动以及物质运输等方面发挥着重要作用,在对病原体识别及清除中也至关重要.为了实现侵染及胞内复制,致病菌包括嗜肺军团菌等已进化出复杂的策略(如效应蛋白或毒力因子)劫持宿主细胞的细胞骨架,以促进胞内复制及细胞间传播.本文主要从细胞骨架组成、嗜肺军团菌致病机制及其对细胞骨架的调控机制等方面进行综述,以期为病原菌感染机制及相关疾病的治疗提供参考.Host cells use antimicrobial proteins,pathogen-restrictive compartmentalization,and cell death in their defense against intracellular pathogens.Many studies in recent years have revealed that four major components of the cytoskeleton—actin,microfilaments,intermediate filaments,and septins—play important roles in in maintaining cell morphology and structure,cell movement,and material transport,they also function in the identification and elimination of pathogens.Pathogens including Legionella pneumophila have evolved sophisticated strategies(e.g.,effector proteins or virulence factors)to hijack the cytoskeleton of host cells for infection,intracellular replication,and intercellular transmission.In this article,we reviewed the components of cytoskeleton,the pathogenesis of L.pneumophila,and the regulation of cytoskeleton by L.pneumophila,which will help understand the mechanisms of pathogen infection and provide strategies for the treatment of related diseases.

关 键 词：细胞骨架 嗜肺军团菌 效应蛋白 

分 类 号：R378[医药卫生—病原生物学]