晕动病的个体易感性分析及物理治疗策略  

Individual susceptibility analysis and physical therapy strategies for motion sickness

作　　者：蒋茂松 于申[2] 齐莉萍 曹妍璐 吴翔 夏书峰 刘文龙[1,5] JIANG MaoSong;YU Shen;QI LiPing;CAO YanLu;WU Xiang;XIA ShuFeng;LIU WenLong(School of Information and Communication Engineering,Dalian University of Technology,Dalian 116024,China;State Key Laboratory of Structural Analysis for Industrial Equipment,Dalian University of Technology,Dalian,116024,China;School of Control Science and Engineering,Dalian University of Technology,Dalian,116024,China;School of Medical Imaging,Xuzhou Medical University,Xuzhou 221004,China;Key Laboratory of Artificial Intelligence,DUT Artificial Intelligence Institute,Dalian 116024,China)

机构地区：[1]大连理工大学信息与通信工程学院,大连116024 [2]大连理工大学工业设备结构分析国家重点实验室,大连116024 [3]大连理工大学控制科学与工程学院,大连116024 [4]徐州医科大学医学影像学院,徐州221004 [5]大连理工大学人工智能大连研究院人工智能重点实验室,大连116024

出　　处：《中国科学:生命科学》2025年第2期375-386,共12页Scientia Sinica(Vitae)

基　　金：中央高校基本科研业务费(批准号:DUT23YG223);国家自然科学基金(批准号:12172082)资助。

摘　　要：晕动病(motion sickness,MS)是一种由前庭系统受到异常运动刺激所引发的综合征.本文通过探究MS易感性差异的标志物,以实现个体MS易感性分析,并寻找无副作用的物理治疗策略.本文将数值模型和眼震实验相结合,明确眼震慢相角速度(slow phase angular velocity,SPV)是个体MS易感性差异的标志物,并将其用于分析个体MS易感性.同时,利用数值模型分析了在低温条件下前庭半规管嵴顶力学行为的变化.在此基础上,本文提出了一种缓解MS症状的前庭系统低温治疗策略,旨在通过调整嵴顶力学性质来缓解MS症状.此外,本文还研发了一种降温设备,并进行了对36名受试者的低温缓解MS的行车实验.实验结果表明,眼震SPV可以作为评估个体MS易感性差异的重要标志物.在正常体温旋转椅实验中,观察到在相同角加速度刺激下,MS易感者的眼震SPV高于非易感者.由于眼震SPV与嵴顶变形之间近似正比例关系,而低温可以增加嵴顶弹性模量.本文通过数值模型验证了在相同角加速度刺激时降温可以减小嵴顶变形,从而降低MS易感者的眼震SPV,使其趋于与非易感者相近的水平.这一发现启发了本研究采用物理降温的方法来缓解MS症状.在低温旋转椅实验中,本文验证了MS易感者的眼震SPV更趋于不易感者.由此,本文研制了一种前庭降温设备,并通过行车实验进一步证明了低温治疗策略的有效性.综上,结合数值模型与眼震实验,提出了一种个体MS易感性分析方法,并提出了一种缓解MS的低温治疗策略,该策略在减轻MS症状方面取得了显著的效果.Motion sickness(MS)is a common and complex syndrome caused by exposure to provocative motion environments.Here,we aimed to explore the biological markers of MS susceptibility to achieve individual susceptibility analysis and propose physical therapy strategies without side effects.We combined the numerical model with the nystagmus test to identify individual susceptibility markers for MS,focusing on the slow-phase angular velocity(SPV)of nystagmus,and applied it to analyze individual differences in susceptibility to MS.Additionally,using the numerical model,we analyzed the mechanical behavior changes of the semicircular canal’s cupula in hypothermic conditions.On the basis of these findings,a local hypothermic strategy was proposed to alleviate MS symptoms.The strategy aims to reduce susceptibility to MS by adjusting the mechanical properties of the cupula,thereby alleviating MS symptoms.We also developed a cooling device and observed 36 subjects’susceptibility to MS in hypothermic conditions through actual driving experiments.The experimental results indicate that SPV can serve as a crucial biomarker for assessing individual differences in MS susceptibility.We found that individuals affected by MS exhibited a higher SPV of nystagmus under the same angular acceleration stimuli than those unaffected by MS in normothermic conditions.Since the SPV of the nystagmus is approximately proportional to the cupula deformation,and cooling can increase the elasticity modulus of the cupula.We verified that cooling can reduce the cupula deformation under the same angular acceleration stimulus through numerical modeling,thereby reducing the SPV in MS-susceptible individuals to levels similar to non-susceptible individuals.This finding inspired us to explore a physical cooling approach to alleviate MS symptoms.In hypothermic conditions,we confirmed that the SPV of MS-susceptible individuals tended to approximate that of non-susceptible individuals.Consequently,we developed a cooling device and further demonstrated the effect

关 键 词：晕动病 数值模型 MS易感性 眼震慢相角速度 治疗策略 

分 类 号：R594.6[医药卫生—内科学]