泊沙康唑药物代谢动力学及其治疗药物监测方法研究进展  

Progress in Pharmacokinetics and Therapeutic Drug Monitoring of Posaconazole

作　　者：赵越桃 Zhao Yuetao(Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China)

机构地区：[1]华中科技大学同济医学院附属协和医院药学部,湖北武汉430022

出　　处：《中外医药研究》2025年第4期166-168,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：该文简要分析了泊沙康唑的药物代谢动力学特点与影响因素,阐述了泊沙康唑的治疗药物监测方法与药物浓度监测时机。指出泊沙康唑在给药过程中需要充分考虑影响因素,注意各药物作用机制,必要时选择注射剂,并加强对肝肾功能不全、儿童和老年等群体不良反应的监测力度。给药初期以及给药后7 d均可获得较好的血药浓度监测结果,对于疾病治疗方案的调整具有积极作用。This paper briefly analyzes the pharmacokinetic characteristics and influencing factors of posaconazole,and elaborates on the monitoring methods and timing of posaconazole concentration.It is emphasized that during the administration of posaconazole,it is essential to fully consider the influencing factors,pay attention to the mechanisms of each drug,select injections when necessary,and enhance the monitoring of adverse reactions in populations such as those with hepatic and renal insufficiency,children,and the elderly.Optimal blood concentration monitoring results can be achieved both at the initial stage of administration and 7 days post-administration,which positively contributes to the adjustment of disease treatment regimens.

关 键 词：泊沙康唑 药物代谢动力学 监测方法 

分 类 号：R978.5[医药卫生—药品]