下丘脑室旁核参与针灸治疗疾病的机制  

Mechanisms by Which Paraventricular Hypothalamic Nucleus Participates in the Acupuncture Treatment of Diseases

作　　者：白子优 张超然 饶弈清 林琪顺 余玲玲 刘嘉宝 景向红[4] 李熳[1] BAI Ziyou;ZHANG Chaoran;RAO Yiqing;LIN Qishun;YU Lingling;LIU Jiabao;JING Xianghong;LI Man(Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Institute of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;College of Acupuncture and Moxibustion and Orthopedics,Hubei University of Chinese Medicine,Wuhan 430061,China;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]华中科技大学同济医学院基础医学院,湖北省和教育部神经系统重大疾病重点实验室,武汉430030 [2]华中科技大学同济医学院附属同济医院中西医结合研究所,武汉430030 [3]湖北中医药大学针灸骨伤学院,武汉430061 [4]中国中医科学院针灸研究所,北京100700

出　　处：《四川大学学报(医学版)》2025年第1期26-34,共9页Journal of Sichuan University(Medical Sciences)

基　　金：国家重点研发计划(No.2022YFC3500704)资助。

摘　　要：近年来,研究表明,针灸可以通过调控下丘脑室旁核(paraventricular hypothalamic nucleus,PVN)来治疗多种疾病,如功能性胃肠道疾病、心血管疾病以及焦虑和抑郁等。针灸可能通过调节PVN中的特定神经元,如促肾上腺皮质激素释放激素(corticotropin releasing hormone,CRH)神经元,或调节PVN相关的神经环路和激素〔如催产素(oxytocin,OXT)、血管升压素(vasopressin,VP)〕的释放,发挥其治疗作用。本文总结了PVN在针灸治疗中的机制,包括其在胃肠道疾病、心血管疾病、负性情绪和疼痛的调控机制。未来研究可深入探究针灸调控PVN治疗疾病的精确机制,如明确信号通路传导的详细过程,探究不同穴位配伍、刺激频率与强度对PVN的特异性影响等。In recent years,a growing body of research has demonstrated that acupuncture can be used to effectively treat a diverse range of diseases,including functional gastrointestinal disorders,cardiovascular diseases,as well as anxiety and depression,through the modulation of the paraventricular hypothalamic nucleus(PVN).Acupuncture may exert its therapeutic effect either by modulating specific neurons within the PVN,such as corticotropin releasing hormone(CRH)neurons,or by regulating the release of hormones,such as oxytocin(OXT)and vasopressin(VP),and the activity of neural circuits associated with the PVN.This review summarizes the mechanisms by which PVN is involved in acupuncture treatment,including its regulatory mechanisms in gastrointestinal diseases,cardiovascular diseases,and negative emotions and pain.Future research should be conducted to further explore the precise mechanisms by which acupuncture regulates PVN to treat diseases,focusing on clarifying the specific processes of signaling pathway transduction,and exploring the specific effects of acupunture of different acupoint combinations and stimulation frequencies and intensity on PVN.

关 键 词：下丘脑室旁核 针灸 高血压 胃肠道 心脏病 综述 

分 类 号：R246[医药卫生—针灸推拿学]