不同角度分析大容量全肺灌洗术对尘肺病的治疗效果  

Analysis on therapeutic effect of whole-lung lavage on pneumoconiosis from different perspectives

作　　者：刘梦 孔晓梅[2] LIU Meng;KONG Xiaomei(First Clinical Medical College,Shanxi Medical University,Taiyuan,Shanxi 030001,China;National Health Commission Key Laboratory of Pneumoconiosis,Shanxi Province Key Laboratory of Respiratory,Department of Respiratory and Critical Care Medicine,First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]国家卫生健康委尘肺病重点实验室,呼吸疾病山西省重点实验室,山西医科大学第一医院呼吸与危重症医学科,山西太原030001

出　　处：《职业与健康》2024年第24期3437-3440,3446,共5页Occupation and Health

基　　金：中央级公益性科研院所科研业务项目(2020-PT320-005)。

摘　　要：尘肺病是我国影响面最广、危害最严重的职业病。尘肺病是由于煤矿工人在职业活动中长期吸入二氧化硅、煤尘或其他粉尘并在肺内储留,刺激肺泡巨噬细胞释放炎症因子,引发肺泡炎症,进而引发肺组织弥漫性、进行性纤维化的一种全身性疾病。大容量全肺灌洗术(whole-lung lavage,WLL)是一种广泛应用于尘肺病患者的治疗手段,其临床效果肯定且安全。本文将从尘肺病患者WLL治疗前后的肺功能、临床症状和生存质量、影像学表现、动脉血气分析、炎性因子5方面的变化情况进行综述,分析WLL对尘肺病的治疗效果。Pneumoconiosis is the most widely affected and hazardous occupational disease in China.Pneumoconiosis is a systemic disease caused by coal miners inhaling silica,coal dust,or other dust for a long time during occupational activities and storing them in the lungs,which stimulates alveolar macrophages to release inflammatory factors,leading to alveolar inflammation and causing diffuse and progressive fibrosis of lung tissue.Whole-lung lavage(WLL)is a widely used treatment for patients with pneumoconiosis,with proven clinical efficacy and safety.This article will review the changes in lung function,clinical symptoms and quality of life,imaging manifestations,arterial blood gas analysis,and inflammatory factors in patients with pneumoconiosis before and after WLL treatment,and analyze the therapeutic effect of WLL on pneumoconiosis.

关 键 词：尘肺 大容量全肺灌洗术 治疗 

分 类 号：R135.2[医药卫生—劳动卫生]