Research Progress on Microfluidic Paper-based Analytical Devices for Point-of-care Testing  

用于即时检验的微流控纸基分析设备的研究进展

作　　者：ZHANG Yuji XU Ruicheng SHAN Dan 张玉基;许瑞呈;单丹(南京理工大学环境与生物工程学院,南京210094)

机构地区：[1]School of Environmental&Biological Engineering,Nanjing University Science&Technology,Nanjing 210094,China

出　　处：《激光生物学报》2025年第1期1-11,共11页Acta Laser Biology Sinica

基　　金：国家自然科学基金面上项目(22274075)。

摘　　要：Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.即时检验(POCT)是指在患者现场或附近进行的一类诊断测试(也称为床边测试),能够通过使用便携式诊断设备在短时间内获得准确的结果,避免将样本送往医学实验室。随着生物化学分析和微流体检测技术的发展,POCT已被广泛用于诊断和监测患者的疾病和健康状况。微流控纸基分析设备(µPADs)因其简单、用户友好、快速准确的结果读取和低成本而在POCT中广受欢迎。在过去的几十年里,一些µPADs已经成功商业化应用,显示出很好的发展前景。本文简要讨论了µPADs的主要类型、制备方法及其检测原理,并列举了几个具有代表性的例子,描绘了µPADs的未来发展前景。

关 键 词：point-of-care testing microfluidic paper-based analytical devices SENSOR personalized medical treatment portable diagnostic equipment 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]