线粒体质量控制系统在子宫内膜异位症中作用机制的研究进展  

Advances in mechanism of mitochondrial qualitycontrol system in endometriosis

作　　者：陈元欢 岳斌 毛海燕[2] 黄灿灿 张小花 冯鹏 武权生 CHEN Yuan-huan;YUE Bin;MAO Hai-yan;HUANG Can-can;ZHANG Xiao-hua;FENG Peng;WU Quan-sheng(Clinical School of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Traditional Medicine Clinic,Gansu Provincial Hospital,Lanzhou 730000,China;Medical college,Hexi University,Zhangye,Gansu 734000,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃省人民医院传统医学诊疗中心,甘肃兰州730000 [3]河西学院医学院,甘肃张掖734000

出　　处：《中国药理学通报》2025年第3期406-410,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82260949);甘肃省自然科学资助基金(No 23JRRA1751);甘肃省中医药科研课题(No GZKP-2023-21);甘肃省中医药研究中心开放课题(No zyzx-2023-09)。

摘　　要：子宫内膜异位症(endometriosis,EMs)是一类雌激素依赖的临床常见病,具有恶性肿瘤的病理特征,对女性的身心健康影响较大。近年来实验探索发现,异位灶在子宫腔外处于缺氧环境,而线粒体作为细胞的“功能工厂”在其种植、侵袭的过程中发挥了重要作用,而包括线粒体氧化应激、动力学、自噬、生物发生及钙平衡在内的线粒体质量控制系统是线粒体功能衡定的关键机制。因此,借助合理、严谨的实验及临床研究,明确线粒体质量控制系统在EMs发生发展中的作用过程,不仅可以帮助明确本病的发病机制,而且可以对该病防治过程中的关键靶点展开探索。该文就线粒体质量控制系统在子宫内膜异位症中的研究进展展开综述,以期为EMs的病因病机及防治策略提供借鉴和理论依据。Endometriosis(EMs)is a common estrogen-dependent clinical disease with the pathological characteristics of malignant tumors,which has great impact on women’s physical and mental health.In recent years,experimental exploration has revealed that ectopic foci are in a hypoxic environment outside the uterine cavity,and mitochondria,as the“functional factories”of the cells,play an important role in the process of planting and invasion,and the mitochondrial quality control system,which includes mitochondrial oxidative stress,kinetics,autophagy,biogenesis and calcium homeostasis,is a key mechanism for the equilibrium of the mitochondrial function.The mitochondrial quality control system,including mitochondrial oxidative stress kinetics,autophagy,biogenesis and calcium homeostasis,is a key mechanism for mitochondrial functional balance.Therefore,to clarify the role of the mitochondrial quality control system in the development of EMs with the help of rational and rigorous experimental and clinical studies can not only help to clarify the pathogenesis of the disease,but also explore the key targets in the prevention and treatment of the disease.Therefore,this article summarizes the research progress of mitochondrial quality control system in endometriosis,with a view to providing reference and theoretical basis for the etiology,pathogenesis and prevention strategies of EMs.

关 键 词：子宫内膜异位症 线粒体质量控制系统 氧化应激 自噬 动力学 生物发生 钙平衡 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R711.71[医药卫生—基础医学]