cGAS-STING通路介导脑缺血/再灌注损伤的机制研究进展  

Research progress on mechanism of cGAS-STING pathwaymediated cerebral ischemia/reperfusion injury

作　　者：黎梦雅 兰瑞[1] 沈晓明[1] 焦水治 刘亚寒 王保奇 LI Meng-ya;LAN Rui;SHEN Xiao-ming;JIAO Shui-zhi;LIU Ya-han;WANG Bao-qi(Dept of Encephalopathy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院脑病科,河南郑州450000 [2]河南中医药大学第一临床医学院,河南郑州450000

出　　处：《中国药理学通报》2025年第3期417-420,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81973618,81503422);河南省中医药科学研究专项课题(No 82022JDZX090)。

摘　　要：环鸟苷酸-腺苷酸合成酶(cyclic GMP-AMP synthase,cGAS)是一种先天免疫传感器,可识别胞质异常dsDNA,通过催化第二信使环鸟甘酸腺苷酸(cyclic GMP-AMP,cGAMP)形成,激活干扰素基因刺激因子(stimulator of interferon genes,STING),释放Ⅰ型干扰素和促炎细胞因子,激活宿主免疫应答,参与脑缺血/再灌注损伤(cerebral ischemia reperfusion injury,CIRI)级联反应。该文对cGAS-STING通路参与CIRI的机制研究进展进行综述,为其治疗提供思路。Cyclic GMP-AMP synthase(cGAS)is a congenital immune sensor that can recognize cytoplasm abnormal dsDNA.By catalyzing the second messenger cyclic GMP-AMP(cGAMP)formation,it activates stimulator of interferon genes(STING),releases type I interferon and inflammatory cytokines,activates the host immune response,and participates in cerebral ischemia reperfusion injury(CIRI)cascade reaction.This article reviews the research progress of the mechanism of cGAS-STING signaling pathway participation in CIRI,hoping to provide ideas for its treatment.

关 键 词：脑缺血/再灌注 cGAS-STING通路 细胞凋亡 神经炎症 铁自噬 钙超载 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R348.1[医药卫生—基础医学] R392.11R743.31