机械牵张干预骨形成相关信号通路的作用机制研究进展  

Research progress on the mechanism of mechanical stretch regulating osteogenic differentiation related signaling pathways

作　　者：李想 孔令俊[2] 孙兴翔 张金磊 邓叶龙 韩升龙 孟汉杰 王植帅 LI Xiang;KONG Ling-jun;SUN Xing-xiang;ZHANG Jin-lei;DENG Ye-long;HAN Sheng-long;MENG Han-jie;WANG Zhi-shuai(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Osteoporosis(geriatric bone),Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医院骨质疏松(老年骨)科,兰州730050

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2025年第1期128-134,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：甘肃省中医院横向课题(20180401);兰州市人才创新创业项目(2023-2-20);兰州市科技计划项目(2023-ZD-49);甘肃省联合基金(24JRRA902)。

摘　　要：骨形成是参与维持机体骨稳态的重要途径之一,其功能障碍可介导多类骨代谢疾患的发生发展。研究发现Wnt/β-连环蛋白(Wnt/β-catenin)、腺苷酸活化蛋白激酶/沉默信息调节因子1(adenylate-activated protein kinase/silent information regulator 1,AMPK/SIRT1)、细胞外调节蛋白激酶1/2-转录因子核心结合因子α1(extracellular regulated protein kinase 1/2-transcription factor core binding factorα1,ERK1/2-Cbfa1)、p38丝裂原蛋白活化激酶(p38 mitogen-activated kinase,p38 MAPK)、核转录因子-κB(nuclear transcription factor-κB,NF-κB)、Notch等多条信号通路均有干预骨形成、调控骨稳态的潜能。机械牵张作为调节细胞增殖、分化的重要手段,运用合理的牵张方式可对参与骨形成、维持骨稳态的多类细胞产生积极调控作用。本文通过对机械牵张干预上述信号通路影响骨形成的相关文献进行综述,旨在进一步明确机械牵张干预骨形成的作用机制,以期为经机械牵张正向调控骨代谢相关疾患的发展态势提供思路和理论依据。Bone formation is one of the important parts involved in the maintenance of bone homeostasis in the body,and its dysfunction can mediate the development of multiple types of bone metabolic disorders.It has been found that various signal pathways such as Wnt/β-catenin,adenylate-activated protein kinase/silent information regulator 1(AMPK/SIRT1),extracellular regulated protein kinase 1/2-transcription factor core binding factorα1(ERK1/2-Cbfa1),p38 mitogen-activated kinase(p38 MAPK),nuclear transcription factor-κB(NF-κB)and Notch have the potential to intervene in bone formation and regulate bone homeostasis.Mechanical stretch,as an important means to regulate cell proliferation and differentiation,can positively regulate multiple types of cells involved in bone formation and maintenance of bone homeostasis by using reasonable stretch methods.In this article the literatures on mechanical stretch intervening in the above signaling pathways affecting bone formation were reviewed,with the aim of further clarifying the mechanism of mechanical stretch intervening in bone formation,so as to provide ideas and theoretical basis for the development of bone metabolism related disorders positively regulated by mechanical distraction.

关 键 词：机械牵张 信号通路 骨形成 骨代谢 

分 类 号：R336[医药卫生—人体生理学]