通过白光干涉仪观察不同参数下CO_(2)点阵激光烧蚀甲面的变化  

Nail changes under different CO_(2) fractional laser parameters using white light interferometry

作　　者：马红艳 王宏伟 MA Hongyan;WANG Hongwei(Department of Dermatology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院皮肤科,北京100730

出　　处：《基础医学与临床》2025年第3期354-359,共6页Basic and Clinical Medicine

摘　　要：目的评估不同CO_(2)点阵激光参数对甲面微小治疗区(MTZ)形成的影响,并比较不同仪器对这些区域效果的观察。方法本研究在牛甲样品上应用60种不同的CO_(2)点阵激光参数组合,包括脉宽100~1000μs和功率10~60 W。随后,通过光学显微镜、倒置显微镜和白光干涉仪观察和比较甲面的MTZ形成及整体变化。分析MTZ与各项激光参数的关系。结果在MTZ观察中,白光干涉仪与倒置显微镜之间存在显著差异(P<0.001)。白光干涉仪在测量微小剥脱柱(MAC)和热凝固带(TCZ)方面展现出更高的准确性和可靠性。CO_(2)点阵激光参数在MAC的形成上也有显著的差异(P<0.001)。其中,脉宽与MTZ的相关性最强(0.65668~0.77262)。脉宽越长,MAC的面积和深度越大,TCZ的厚度也相应增加。结论白光干涉仪在评估CO_(2)点阵激光对组织深度影响上具有显著优势。这些发现为优化激光参数在甲真菌病治疗提供了有价值的参考,并有助于提高此类治疗的安全性和有效性。Objective To evaluate the impact of different CO_(2) fractional laser parameters on the formation of microscopic treatment zone(MTZ)on the nail surface and to compare the observations of these areas using various instruments.Methods This study applied 60 different combinations of CO_(2) fractional laser parameters,including pulse widths ranging from 100-1000μs and powers from 10-60 W,on bovine hoof samples.The formation and overall changes of MTZ on the nail surface were subsequently observed and compared using optical microscopy,inverted microscopy,and white light interferometry.The relationships between MTZ and various laser parameters were analyzed.Results Significant statistical differences were observed between white light interferometry and inverted microscopy in MTZ assessment(P<0.001).White light interferometry demonstrated greater accuracy and reliability in measuring micro-ablative column(MAC)and thermal coagulation zone(TCZ).There were also significant statistical differences in MAC formation based on CO_(2) fractional laser parameters(P<0.001),with the strongest correlation found between pulse width and MTZ(0.65668-0.77262).Longer pulse widths correlated with larger MAC areas and depths,as well as increased TCZ thickness.Conclusions White light interferometry shows significant advantages in assessing the impact of CO_(2) fractional laser ablation on tissue depth.These findings provide valuable insights for optimizing laser parameters in the treatment of nail disorders and contribute to enhancing the safety and efficacy of such therapies.

关 键 词：CO_(2)点阵激光 甲通道 热效应 白光干涉仪 

分 类 号：R751[医药卫生—皮肤病学与性病学]