纤维蛋白原与脊柱退行性病变患者骨密度的关系  

Relationship between fibrinogen and bone mineral density in patients with spinal degenerative disease

作　　者：徐东江 刘武征 王克迪[3] XU Dongjiang;LIU Wuzheng;WANG Kedi(Department of Blood Transfusion,Beijing Jishuitan Hospital,Capital Medical University,Beijing 100035;Department of Clinical Laboratory,Beijing Jishuitan Hospital,Capital Medical University,Beijing 100035;Department of Clinical Laboratory,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京积水潭医院输血科,北京100035 [2]首都医科大学附属北京积水潭医院检验科,北京100035 [3]首都医科大学附属北京友谊医院临床检验中心,北京100050

出　　处：《基础医学与临床》2025年第3期360-364,共5页Basic and Clinical Medicine

基　　金：首都医科大学附属北京积水潭医院院级青年基金(QN202417)。

摘　　要：目的探讨凝血系统检测标志物与脊柱退行性病变患者骨密度(BMD)的关系。方法选取2019年3月至10月,于北京积水潭医院脊柱外科行手术治疗的脊柱退行性病变患者,共有251例同时具备骨密度数据和凝血系统检测数据的患者入组,分析凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(Fib)以及凝血酶时间(TT)检测指标在不同性别不同骨密度分组中的分布。结果实验室凝血指标回顾性分析表明,男性患者中只有纤维蛋白原含量随骨密度降低而增高(P<0.05)。女性患者的凝血酶原时间和活化部分凝血酶原时间随骨密度降低而降低,但女性患者组间差异无统计学意义,而纤维蛋白原含量随骨密度降低而增加(P<0.05)。根据骨密度结果将患者分为骨质疏松组和非骨质疏松组,以骨密度分组二分类变量与患者凝血指标进行皮尔逊相关分析,两种性别患者骨密度分组与纤维蛋白原定量都呈显著负相关(P<0.05)。结论脊柱退行性病变患者的纤维蛋白原,随着骨密度降低而显著增高,或许可以作为该疾病骨密度分级的预测指标。Objective To investigate the correlation between coagulation system biomarkers and bone mineral density(BMD)in patients with spinal degenerative diseases.Methods A total of 251 patients who underwent surgical treatment for spinal degenerative diseases at the Department of Spinal Surgery,Beijing Jishuitan Hospital,from March to October 2019,were enrolled in this study.These patients had both BMD data and coagulation system test results available.The distribution of coagulation indicators,including prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib),and thrombin time(TT),was analyzed across different gender and BMD groups.Results A retrospective analysis of laboratory coagulation indicators revealed that in male patients,only fibrinogen levels were significantly increased with the reduction of BMD(P<0.05).PT and APTT did't show significant differences in female patients across BMD groups,but fibrinogen levels increased with the decrease in BMD(P<0.05).Patients were classified into osteoporosis and non-osteoporosis groups based on their BMD results.Pearson correlation analysis was performed between the binary variable of BMD grouping and patients'coagulation indicators.The results showed a significant negative correlation between BMD grouping and fibrinogen levels in both genders(P<0.05).Conclusions Fibrinogen level in patients with spinal degenerative diseases significantly increases as BMD decreases,suggesting that fibrinogen may serve as a predictive biomarker for BMD stratification in these patients.

关 键 词：纤维蛋白原 骨质疏松 脊柱退行性病变 

分 类 号：R446.1[医药卫生—诊断学]