富血小板血浆联合间充质干细胞修复子宫内膜损伤的机制  

Platelet-rich plasma combined with mesenchymal stem cells to repair endometrial injury

作　　者：叶可 魏华芳 宋成文 YE Ke;WEI Huafang;SONG Chengwen(Medical School,Wuhan University of Science and Technology,Wuhan 430065;Department of Obstetrics and Gynecology,General Hospital of Central Theater Command of Chinese PLA,Wuhan 430070,China)

机构地区：[1]武汉科技大学医学院,湖北武汉430065 [2]中国人民解放军中部战区总医院妇产科,湖北武汉430070

出　　处：《基础医学与临床》2025年第3期390-394,共5页Basic and Clinical Medicine

基　　金：2024年湖北省自然科学基金创新发展联合基金重点项目(2024AFD276)。

摘　　要：子宫内膜损伤性疾病是子宫内膜基底层损伤后引起的子宫内膜薄弱以及子宫壁之间相互粘连的一类宫腔疾病,目前临床上使用的药物治疗、宫腔镜手术等方法均未能达到理想的疗效。间充质干细胞(MSCs)及富血小板血浆(PRP)能够分泌多种活性因子参与调节子宫内膜的炎性反应和免疫应答,促进子宫内膜增殖与修复,且二者之间存在相互促进作用,联合使用可为子宫内膜损伤性疾病的临床治疗提供新的思路。Endometrial injury disease is a kind of uterine disease of thin endometrium and intrauterine adhesion caused by endometrial basal layer damage.The current clinical use of drug therapy and hysteroscopy surgery can not have good curative effects.Mesenchymal stem cells(MSCs)and platelet-rich plasma(PRP)can secrete a variety of active factors to regulate the inflammatory response and immune response of endometrial,promote endometrial proliferation and repair,and there is a mutual promoting effect between the two.Combined use can provide a new idea for the clinical treatment of endometrial injury diseases.

关 键 词：子宫内膜损伤 富血小板血浆 间充质干细胞 

分 类 号：R711.74[医药卫生—妇产科学]