感染人类免疫缺陷病毒的儿童乙型肝炎疫苗免疫效果研究进展  

Research progress in the immune effect of hepatitis B vaccine in children with human immunodeficiency virus infection

作　　者：宋晓 李惠琴 SONG Xiao;LI Huiqin(Kunming Medical University,Kunming,Yunnan 650500,China;不详)

机构地区：[1]昆明医科大学,云南昆明650500 [2]云南省传染病医院艾滋病关爱中心,云南昆明650300

出　　处：《中国病毒病杂志》2024年第6期585-589,共5页Chinese Journal of Viral Diseases

基　　金：昆明医科大学科技创新团队建设项目(CXTD202111)。

摘　　要：婴幼儿时期感染乙型肝炎(乙肝)病毒易导致慢性化,且病毒难清除,目前预防乙肝病毒感染的有效措施是接种乙肝疫苗。人类免疫缺陷病毒(human immunodeficiency virus,HIV)合并乙肝病毒(hepatitis B virus,HBV)共感染相互影响彼此进程。HIV感染儿童乙肝疫苗接种免疫效果问题一直受到关注,本文对HIV/HBV共感染流行、乙肝疫苗接种免疫情况、影响因素等进行综述,为进一步研究提高人类免疫缺陷病毒感染儿童乙肝疫苗免疫效果问题提供思路。Hepatitis B virus(HBV)infection during infancy and childhood is prone to extreme chronicity and poses challenges for viral clearance.The current effective preventive measure to prevent HBV infection is vaccination with the hepatitis B vaccine.The coexistence of human immunodeficiency virus(HIV)and HBV can influence the progression of both infections.The immunogenicity of hepatitis B vaccination in children infected with HIV has garnered significant attention.This paper reviews the prevalence of HIV/HBV co-infection,the immunization status of hepatitis B vaccination,and the various factors affecting vaccine efficacy so as to provide ideas for further research on improving the immunization effect of hepatitis B vaccination in children with HIV.

关 键 词：人类免疫缺陷病毒 乙型肝炎病毒 乙型肝炎疫苗 儿童 乙型肝炎病毒表面抗体 

分 类 号：R512.91[医药卫生—内科学]