芪冬颐心颗粒联合索他洛尔对PAF的临床效果研究  

Clinical effect of Qidongyixin granule combined with sotalol on PAF

作　　者：辛浩 李阳 何克强 马艺语 焦媛媛 Xin Hao;Li Yang;He Keqiang;Ma Yiyu;Jiao Yuanyuan(Department of Cardiovascular Medicine,Xianyang Hospital of Yan′an University,Xianyang 712000,China)

机构地区：[1]延安大学咸阳医院心血管内科,咸阳712000

出　　处：《中国临床实用医学》2024年第6期49-53,共5页China Clinical Practical Medicine

摘　　要：目的探讨芪冬颐心颗粒联合索他洛尔治疗阵发性心房颤动(PAF)的临床效果。方法本研究为随机对照研究,选取2023年6月至2024年6月延安大学咸阳医院心血管内科收治的76例PAF患者,男47例,女29例,年龄(61.59±4.81)岁,年龄范围为55~68岁。采用抽签分组方案将患者随机分为观察组与对照组,每组38例。对照组患者采用索他洛尔治疗,观察组患者采用芪冬颐心颗粒联合索他洛尔治疗,比较两组患者治疗有效率、中医证候积分、静息心室率、P波最大时限(Pmax)、P波离散度(Pd)、明尼苏达州心力衰竭生活质量问卷(MLHFQ)评分。结果观察组患者的治疗有效率[97.4%(37/38)]高于对照组[81.6%(31/38)],差异有统计学意义(P<0.05)。治疗后观察组患者的中医证候积分均低于对照组,静息心室率[(75.24±5.38)次/分]、Pmax[(101.25±6.85)ms]、Pd[(28.96±2.71)ms]低于对照组[(78.91±6.44)次/分、(108.92±9.75)ms、(34.12±4.95)ms],MLHFQ评分低于对照组,差异均有统计学意义(P<0.05)。结论PAF患者采用芪冬颐心颗粒联合索他洛尔治疗效果显著,可缓解多种症状,改善心电图检查结果,提升生活质量。Objective:To explore the clinical effect of Qidongyixin granule combined with sotalol in the treatment of paroxysmal atrial fibrillation(PAF).Methods:This study was a randomised controlled study,a total of 76 patients with PAF were admitted to the department of Cardiovascular Medicine at Xianyang Hospital of Yan′an University from June 2023 to June 2024,including 47 males and 29 females,aged(61.59±4.81)years old,with an age range of 55 to 68 years old.The patients were divided into observation group and control group by drawing scheme,with 38 samples in both group.The patients in the control group were treated with sotalol,and the patients in the observation group were treated with Qidongyixin granule combined with sotalol.Compared with the two groups,the total response rate,Chinese medical science syndrome score,resting ventricular rate,maximum time limit of P wave(Pmax),P wave dispersion(Pd),and Minnesota heart failure quality of life questionnaire(MLHFQ)score.Results:The treatment efficiency of patients in the observation group[97.4%(37/38)]was higher than that of the control group[81.6%(31/38)],and the difference was statistically significant(P<0.05).The TCM evidence points of patients in the observation group were lower than those of the control group after treatment,the resting ventricular rate[(75.24±5.38)beats/min],Pmax[(101.25±6.85)ms],and Pd[(28.96±2.71)ms]were lower than those of the control group[(78.91±6.44)beats/min,(108.92±9.75)ms,(34.12±4.95)ms],and the MLHFQ scores of the patients in the observation group were lower than those of the control group after treatment,and the differences were statistically significant(P<0.05).Conclusions:Patients with PAF,it can relieve many symptoms,improve ECG results and improve quality of life.

关 键 词：索他洛尔 芪冬颐心颗粒 阵发性心房颤动 

分 类 号：R541.75[医药卫生—心血管疾病]