粪菌移植治疗儿童常见神经系统疾病的研究进展  

Research progress on fecal microbiota transplantation for the treatment of common neurological disorders in children

作　　者：徐磊 刘振寰[2] 蒲昭霞 余志华[3] 杨祥正 于智羽 XU Lei;LIU Zhenhuan;PU Zhaoxia;YU Zhihua;YANG Xiangzheng;YU Zhiyu(Department of Developmental Behavior,Chengdu Southwest Children’s Rehabilitation Hospital,Sichuan Province,Chengdu 610000,China;Department of Pediatrics,Nanhai Women and Children’s Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine,Guangdong Province,Foshan 528000,China;Children’s Rehabilitation Center,Chengdu First People’s Hospital,Sichuan Province,Chengdu 610001,China;Department of Pediatrics,Shenzhen Hospital,Beijing University of Chinese Medicine,Guangdong Province,Shenzhen 518172,China)

机构地区：[1]成都高新西南儿童康复医院发育行为科,四川成都610000 [2]广州中医药大学附属南海妇儿医院儿科,广东佛山528000 [3]成都市第一人民医院儿童康复中心,四川成都610001 [4]北京中医药大学深圳医院儿科,广东深圳518172

出　　处：《妇儿健康导刊》2025年第3期17-20,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：中国优生优育协会科研项目(2024K027);成都市医学科研课题(2024139);成都高新区医学科研课题(2024020,2024021)。

摘　　要：粪菌移植(FMT)是将健康供体粪便中的肠道菌群移植到患者肠道内,实现肠道内外疾病的治疗,可改善神经系统疾病症状。已有研究发现,抑郁、焦虑、孤独症谱系障碍、抽动障碍、注意缺陷多动障碍和癫痫等常见神经系统疾病患儿的道微生物群存在异常,FMT能够改善其疾病症状。本文对FMT治疗以上疾病的相关研究进行综述,为未来儿童神经系统疾病临床治疗提供新的思路。Fecal microbiota transplantation(FMT)is the transplantation of gut flora from the feces of a healthy donor into the patient’s gut to achieve treatment of intestinal and extra-intestinal diseases,which can improve symptoms of neurological disorders.It has been found that children with common neurological disorders such as depression,anxiety,autism spectrum disorders,tic disorders,attention deficit hyperactivity disorder,and epilepsy have abnormalities in their gut microbiota,and that FMT can improve their disease symptoms.This paper reviews the studies related to FMT for the treatment of the above disorders to provide new ideas for the future clinical treatment of pediatric neurological disorders.

关 键 词：粪菌移植 肠-脑轴 神经系统疾病 儿童 研究进展 

分 类 号：R729[医药卫生—儿科]