定量磁敏感图在认知障碍疾病脑铁沉积中的研究进展  

Recent advance in quantitative susceptibility mapping in brain iron deposition associated with cognitive disorders

作　　者：孙若寒 孟垚 谢小华 许静[3] 董艳红[3] Sun Ruohan;Meng Yao;Xie Xiaohua;Xu Jing;Dong Yanhong(Graduate School,Hebei Medical University,Shijiazhuang 050017,China;Graduate School,Hebei North University,Zhangjiakou 075000,China;Department of Neurology,Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学研究生学院,石家庄050017 [2]河北北方学院研究生学院,张家口075000 [3]河北省人民医院神经内科,河北省脑网络与认知障碍重点实验室,石家庄050051

出　　处：《中华神经医学杂志》2025年第2期180-186,共7页Chinese Journal of Neuromedicine

基　　金：科技创新2030-"脑科学与类脑研究"重大项目(2021ZD0201807);河北省自然科学基金(H2020307042、H2022307075)。

摘　　要：铁在大脑内参与能量代谢、神经递质传递以及髓鞘形成等多项活动,外周铁代谢紊乱及脑铁过量蓄积将通过炎症反应及异常蛋白质表达等病理机制造成认知行为能力下降,导致认知障碍疾病。定量磁敏感图(QSM)作为新型的无创磁共振成像技术,可通过定量测量脑铁沉积,明确认知障碍疾病与铁稳态失衡之间的关系,为临床疾病诊治提供依据。本文现围绕QSM技术在认知障碍疾病脑铁沉积评估中的应用进展进行综述。Iron is involved in several activities in the brain,including energy metabolism,neurotransmitter transmission,and myelination.Disorder of peripheral iron metabolism and excessive iron accumulation in the brain can reduce cognitive and behavioral ability through pathological mechanisms such as inflammatory response and abnormal protein expression,leading to cognitive disorders.Quantitative susceptibility mapping(QSM),as a new non-invasive magnetic resonance technique,can quantitatively measure brain iron deposition,clarify the relationship between cognitive disorders and iron homeostasis imbalance,and provide a basis for clinical diagnosis and treatment of the diseases.This article reviews the latest research progress of QSM in brain iron deposition associated with cognitive disorders.

关 键 词：定量磁敏感图 铁沉积 认知障碍 中枢神经系统 

分 类 号：R74[医药卫生—神经病学与精神病学]