间充质干细胞外泌体在阿尔茨海默病中的研究进展  

Recent advance in mesenchymal stem cell exosome in Alzheimer's disease

作　　者：胡诗俊 李虞蒙 刘涛[2] Hu Shijun;Li Yumeng;Liu Tao(Department of Neurology,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China;Medical Care Center,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China)

机构地区：[1]海南医科大学附属海南医院,海南省人民医院神经内科,海口570311 [2]海南医科大学附属海南医院,海南省人民医院医疗保健中心,海口570311

出　　处：《中华神经医学杂志》2025年第2期201-206,共6页Chinese Journal of Neuromedicine

基　　金：海南省自然科学基金青年项目(822QN459)。

摘　　要：阿尔茨海默病(AD)是神经系统第一大退行性疾病,目前仍缺乏有效治疗药物。保护神经元和突触是逆转AD进展的关键。间充质干细胞外泌体(MSC-Exo)富含包括蛋白质、RNAs、DNAs等在内的多种干细胞成分,因其强大的促进神经修复和抑制神经炎症能力而有望成为AD治疗的潜在选择。本文对MSC-Exo的生物学特征及其在AD治疗方面的应用进行综述,以期为MSC-Exo在AD的转化医学研究和临床应用提供参考。Alzheimer's disease(AD)is the leading neurodegenerative disorder in the nervous system,and there is still a lack of effective therapeutic drugs.Protecting neurons and synapses is crucial in reversing AD progression.Mesenchymal stem cell-derived exosome(MSC-Exo)is rich in various stem cell components such as proteins,RNAs,and DNAs;due to its strong ability in promoting nerve repair and inhibiting neuroinflammation,MSC-Exo is expected to become a potential choice for AD treatment.This article elaborates on the biological characteristics of MSC-Exo and its application and progress in AD treatment,aiming to provide reference for translational medicine research and clinical application of MSC-Exo in AD.

关 键 词：阿尔茨海默病 间充质干细胞外泌体 间充质干细胞 纳米药物 工程化外泌体 治疗机制 

分 类 号：R73[医药卫生—肿瘤]