谷氨酰转肽酶与中老年人群新发糖尿病风险相关性的研究  

Association between glutamyl transpeptidase and risk of new onset diabetes in middle aged and elderly population

作　　者：曲建昌 窦京涛[2] 王安平[2] 谷伟军[2] 吕朝晖[2] 母义明[2] QU Jianchang;DOU Jingtao;WANG Anping(Department of Endocrinology,The 305 Hospital of People's Liberation Army,Beijing 100017,China)

机构地区：[1]北京解放军第三〇五医院内分泌科,北京100017 [2]解放军总医院第一医学中心内分泌科

出　　处：《中国糖尿病杂志》2025年第1期23-27,共5页Chinese Journal of Diabetes

基　　金：解放军第三〇五医院院内基金重点项目(21YNZD01)。

摘　　要：目的探讨谷氨酰转肽酶(GGT)与中老年人群新发DM风险的相关性。方法本研究为回顾性队列研究,基线数据来源为“中国2型糖尿病患者肿瘤发生风险的流行病学研究(REACTION)”北京分中心人群,纳入非DM人群6425名为研究对象,参照GGT水平以四分位数法分为G1(GGT<14.6 U/L,n=1601)、G2(14.6 U/L≤GGT<19.3 U/L,n=1601)、G3(19.3 U/L≤GGT<27.3 U/L,n=1613)、G4(GGT≥27.3 U/L,n=1610)组,平均随访3.2年。结果随访时新发DM患者556例,累积发病率8.7%。Logistic回归分析显示,GGT是非DM人群新发DM的独立危险因素,G3、G4组新发DM的风险分别是G1组的1.730倍(95%CI 1.321~2.265,P<0.001)和1.960倍(95%CI 1.493~2.587,P<0.001)。亚组分析显示,GGT是IGR人群新发DM的独立危险因素,G3、G4组新发DM的风险分别是G1组的1.530倍(95%CI 1.123~2.094,P=0.008)和1.750倍(95%CI 1.271~2.415,P=0.001)。GGT与正常糖耐量人群新发DM不相关(P>0.05)。结论GGT水平是非DM及IGR人群新发DM的危险因素。Objective To analyze the association between glutamyl transpeptidase(GGT)and the risk of newly diagnosed diabetes mellitus(DM)in middle aged and elderly population.Methods A retrospective cohort study was conducted,with baseline data sourced from the Beijing sub center population of the“Risk Evaluation of Cancersin Chinese Diabetic Individuals:A Longitudinal Study(REACTION)”.A total of 6425 non DM individuals were enrolled in this study.All the participantswere divided into four groups according to GGT levels:G1(GGT<14.6 U/L,n=1601),G2(14.6 U/L≤GGT<19.3 U/L,n=1601),G3(19.3 U/L≤GGT<27.3 U/L,n=1613)and G4(GGT≥27.3 U/L,n=1610)group.They were followed up for 3.2 years.Results During follow-up,556 new DM cases were found,with a cumulative incidence rate of 8.7%.Logistic regression analysis showed that GGT was an independent risk factor for new DM in the non DM population,the risk of new DM in the G3,G4 groups was 1.730 times(95%CI 1.321~2.265,P<0.001)and 1.960 times(95%CI 1.493~2.587,P<0.001)of G1 group,respectively.GGT is also an independent risk factor for new DM in the impaired glucose regulation(IGR),the risk of new DM was 1.530 times higher in the G3 group(95%CI 1.123~2.094,P=0.008),and 1.750times higher in the G4 group(95%CI 1.271~2.415,P=0.001)than in the G1 group.GGT is not an independent risk factor for new DM in participants with normal glucose tolerance(P>0.05).Conclusions GGT is a risk factor for new onset DM in IGR population.

关 键 词：谷氨酰转肽酶 糖尿病 危险因素 

分 类 号：R587.1[医药卫生—内分泌]