Daphenylline的全合成研究进展  

Research Progress in Total Synthesis of Daphenylline

作　　者：刘钊 何述钟 LIU Zhao;HE Shu-zhong(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550000,China)

机构地区：[1]贵州大学药学院,贵州贵阳550000

出　　处：《化学试剂》2025年第3期1-12,共12页Chemical Reagents

基　　金：贵州省基础研究(自然科学)项目(ZK〔2021〕一般039)。

摘　　要：虎皮楠生物碱是一类重要的天然产物,具有多种药理活性。Daphenylline是该类生物碱家族中唯一拥有苯环结构的成员,具有6/6/6/5/7/5六环笼状骨架,6个手性中心。因其独特的结构,自分离报道以来,受到国内外有机合成化学家的密切关注。研究者们利用了6π电开环/芳构化、氧化去芳构化环化、Robinson环化/芳构化、Diels-Alder/芳构化、Cope重排等反应,完成了daphenylline的全合成。基于近年来的合成研究,对daphenylline的合成路线和合成策略进行归纳总结,为今后此类生物碱分子的合成研究提供参考。Daphniphyllum alkaloids are an important class of natural products with a variety of pharmacological activities.Daphenylline is the only member with a benzene ring structure in the alkaloid family,possessing a 6/6/6/5/7/5 six-ring cage skeleton and six chiral centers.Daphenylline has attracted great attention owing to its unique chemical structure from chemist in organic synthesis both at home and abroad since its first isolation.They have implemented the total synthesis of the daphenylline by 6πelectrocyclic ring opening/aromatization,oxidative dearomatization cyclization,Robinson cyclization/aromatization,Diels-Alder/aromatization,and Cope rearrangement.Based on the synthetic research in recent years,the synthetic route and strategy of daphenylline were summarized to provide a reference for the future synthesis of this type of alkaloid molecules.

关 键 词：daphenylline 虎皮楠生物碱 串联环化反应 氮杂[3.3.1]桥环 全合成 

分 类 号：O629.3[理学—有机化学]