盐酸西替利嗪联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床效果  

Clinical effect of Cetirizine Hydrochloride combined with Montelukast Sodium in the treatment of children with cough variant asthma

作　　者：丁俊琼 DING Junqiong(Department of Pediatrics,Shanghai Fengxian District Fengpu Street Community Health Service Center,Shanghai 201401,China)

机构地区：[1]上海市奉贤区奉浦街道社区卫生服务中心儿科,上海201401

出　　处：《妇儿健康导刊》2025年第4期102-106,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨盐酸西替利嗪联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床效果。方法选取2023年12月至2024年9月在上海市奉贤区奉浦街道社区卫生服务中心就诊的74例咳嗽变异性哮喘患儿作为研究对象,依据奇偶数法分为对照组与研究组,每组各37例。对照组采用常规治疗+孟鲁司特钠治疗,研究组在对照组基础上采用盐酸西替利嗪治疗。比较两组临床疗效、临床症状消失时间、炎症指标水平及不良反应发生情况。结果研究组临床总有效率高于对照组(P<0.05)。研究组哮喘、咳嗽、哮鸣音消失时间均较对照组短(P<0.05)。治疗后,两组C反应蛋白、嗜酸性粒细胞计数、白细胞、血清淀粉样蛋白A水平均较治疗前低,且研究组水平较对照组低(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论盐酸西替利嗪联合孟鲁司特钠治疗小儿咳嗽变异性哮喘能有效提高治疗效果,加速临床症状缓解,减轻炎症反应。Objective To explore the clinical effect of Cetirizine Hydrochloride combined with Montelukast Sodium in the treatment of children with cough variant asthma.Methods A total of 74 children with cough variant asthma who were treated in Shanghai Fengxian District Fengpu Street Community Health Service Center from December 2023 to September 2024 were selected as the study objects.According to the odd and even method,the children were divided into the control group and the study group,with 37 cases in each group.The control group was treated with conventional treatment+Montelukast Sodium,and the study group was treated with Cetirizine Hydrochloride on the basis of the control group.The clinical efficacy,clinical symptom disappearance time,levels of inflammatory indicators,and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate in the study group was higher than that in the control group(P<0.05).The disappearance time of asthma,cough,and wheezing in the study group was shorter than that in the control group(P<0.05).After treatment,the levels of C-reactive protein,eosinophil count,white blood cell,and serum amyloid A of the two groups were lower than those before treatment,and the levels of the study group were lower than those of the control group(P<0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of children with cough variant asthma,the combination of Cetirizine Hydrochloride and Montelukast Sodium can effectively improve the therapeutic effect,accelerate the relief of clinical symptoms,and reduce inflammation reaction.

关 键 词：盐酸西替利嗪 孟鲁司特钠 小儿咳嗽变异性哮喘 炎症指标 

分 类 号：R725.6[医药卫生—儿科]