羟考酮联合七氟烷面罩吸入在小儿无痛纤维支气管镜检查术中的应用效果  

Application Effect of Oxycodone Combined with Sevoflurane Mask Inhalation in Painless Fiberoptic Bronchoscopy in Children

作　　者：孙易文 裘学 吴硕雄 SUN Yiwen;QIU Xue;WU Shuoxiong(Children's Hospital Affiliated to Jiangnan University,Wuxi 214023,China;不详)

机构地区：[1]江南大学附属儿童医院(无锡市儿童医院),江苏无锡214023

出　　处：《中外医学研究》2025年第5期1-4,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：恩泽疼痛管理医学研究项目(ezmr2022-029)。

摘　　要：目的:探讨在小儿无痛纤维支气管镜检查术中羟考酮联合七氟烷面罩吸入的应用效果。方法:选取2021年1月—2023年12月江南大学附属儿童医院62例行无痛纤维支气管镜检查术的患儿,按照随机数表法分为两组,对照组(30例)采用七氟烷面罩吸入,研究组(32例)联用羟考酮。对比两组苏醒质量、不良反应、血流动力学及氧化应激状态。结果:研究组苏醒时间、呼吸恢复时间早于对照组,躁动评分低于对照组,Ramsay镇静评分高于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。两组麻醉诱导前5 min(T_(1))、麻醉后5 min(T_(2))收缩压、心率比较,差异无统计学意义(P>0.05);两组T_(2)心率和收缩压低于T_(1),入镜后5 min(T_(3))收缩压、心率高于T_(2),退镜后1 h(T_(4))收缩压、心率高于T_(3),差异有统计学意义(P<0.05);研究组T_(3)收缩压、心率低于对照组,T_(4)收缩压、心率高于对照组,差异有统计学意义(P<0.05)。T_(4),两组去甲肾上腺素(norepinephrine,NE)和皮质醇(cortisol,Cor)水平均高于T_(3),但研究组NE、Cor水平低于对照组,差异有统计学意义(P<0.05)。结论:羟考酮联合七氟烷面罩吸入在小儿无痛纤维支气管镜检查术中的应用效果较好,能够显著稳定患儿血流动力学,缓解其氧化应激刺激,提高苏醒质量,并降低检查过程中不良反应发生风险。Objective:To explore the combined application effect of Oxycodone and Sevoflurane mask inhalation in painless fiberoptic bronchoscopy in children.Method:A total of 62 children who underwent painless fiberoptic bronchoscopy in Children's Hospital Affiliated to Jiangnan University from January 2021 to December 2023 were selected and they were randomly divided into two groups by using the random number table method.The control group(30 cases)received Sevoflurane mask inhalation,while the study group(32 cases)received combination of Oxycodone.The quality of recovery,adverse reactions,hemodynamics and oxidative stress were compared between the two groups.Result:The recovery time and respiratory recovery time of the study group were earlier than the control group,the agitation score was lower than the control group,and the Ramsay sedation score was higher than the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in study group was lower than that in control group,and the difference was statistically significant(P<0.05).At 5 min before anesthesia induction(T_(1))and 5 min after anesthesia(T_(2)),there were no significant differences in systolic blood pressure and heart rate between the two groups(P>0.05).The heart rate and systolic blood pressure at T_(2) were lower than those at T_(1),the systolic blood pressure and heart rate at 5 min after admission(T_(3))were higher than those at T_(2),and the systolic blood pressure and heart rate at 1 h after withdrawal(T_(4))were higher than those at T_(3),the differences were statistically significant(P<0.05).At T_(3),systolic blood pressure and heart rate in the study group were lower than those in the control group,and at T_(4),systolic blood pressure and heart rate were higher than those in the control group,the differences were statistically significant(P<0.05).At T_(4),the levels of norepinephrine(NE)and cortisol(Cor)in the two groups were higher than those at T_(3),but the levels of NE and Cor in research group were lo

关 键 词：羟考酮 七氟烷面罩吸入 小儿无痛纤维支气管镜检查术 血流动力学 氧化应激刺激 不良反应 

分 类 号：R47[医药卫生—护理学]