健脾安肾汤对糖尿病合并骨质疏松的疗效及骨代谢的影响  

Effect on Efficacy and Bone Metabolism of Jianpi Anshen Decoction on Diabetes Mellitus Complicated with Osteoporosis

作　　者：林建亮 王磊 曹明明 LIN Jianliang;WANG Lei;CAO Mingming(Qingzhou Municipal Hospital,Qingzhou 262500,China;不详)

机构地区：[1]青州市立医院,山东青州262500 [2]山东省第三荣军优抚医院 [3]德州市陵城区中医院

出　　处：《中外医学研究》2025年第5期47-50,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨健脾安肾汤对糖尿病合并骨质疏松患者的疗效及对骨代谢的影响。方法:选取2020年4月—2022年7月青州市立医院收治的66例糖尿病合并骨质疏松患者作为研究对象,按随机数表法将其分为对照组和观察组,各33例。对照组采取常规降糖+碳酸钙D_(3)片治疗,观察组在对照组基础上给予健脾安肾汤治疗,两组均连续治疗4个月。观察两组临床疗效,比较两组治疗前、治疗4个月后(治疗后)骨代谢指标[血钙(Ca)、血磷(P)、碱性磷酸酶(ALP)]、骨密度(BMD)、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)],并记录不良反应。结果:观察组总有效率比对照组高,差异有统计学意义(P<0.05);治疗后,两组Ca、ALP、BMD较治疗前升高,且观察组比对照组高,两组P、FPG、2 h PG水平较治疗前降低,且观察组比对照组低,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:健脾安肾汤可提高糖尿病合并骨质疏松患者临床疗效,控制血糖水平,调节骨代谢,且不会增加不良反应。Objective:To explore the effect on efficacy and bone metabolism of Jianpi Anshen Decoction on diabetes mellitus with osteoporosis.Method:A total of 66 patients with diabetes mellitus complicated with osteoporosis who admitted to Qingzhou Municipal Hospital from April 2020 to July 2022 were selected as the research objects,and they were divided into the control group and the observation group according to the random number table method,with 33 cases in each group.The control group was treated with conventional glucose-lowering therapy+Calcium Carbonate D_(3) Tablets,and the observation group was treated with Jianpi Anshen Decoction on the basis of the control group,two groups were treated continuously for 4 months.The clinical efficacy of two groups were evaluated,and the bone metabolism indexes[blood calcium(Ca),blood phosphorus(P),alkaline phosphatase(ALP)],bone mineral density(BMD),blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2 h PG)]before treatment and 4 months after treatment(after treatment)were compared between two groups,and the adverse reactions were recorded.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of Ca,ALP and BMD in two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,the levels of P,FPG and 2 h PG in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Jianpi Anshen Decoction can improve the clinical efficacy of diabetes mellitus complicated with osteoporosis patients,control blood glucose level,regulate bone metabolism,and will not increase adverse reactions.

关 键 词：糖尿病 骨质疏松 健脾安肾汤 骨代谢 

分 类 号：R58[医药卫生—内分泌]