MP-IgM、25-OH-VD、IL-6在肺炎支原体肺炎患儿中的临床应用价值  

Clinical Application Value of MP-IgM,25-OH-VD and IL-6 in Children with Mycoplasma Pneumoniae Pneumonia

作　　者：陈智阳[1] 徐燕军[1] CHEN Zhiyang;XU Yanjun(The First Affiliated Hospital of Xiamen University,Xiamen 361003,China;不详)

机构地区：[1]厦门大学附属第一医院,福建厦门361003

出　　处：《中外医学研究》2025年第5期74-77,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究支原体免疫球蛋白M抗体(MP-IgM)、25-羟基维生素D(25-OH-VD)、白细胞介素-6(IL-6)在肺炎支原体肺炎(MPP)患儿中的临床应用价值。方法:回顾性分析2023年2月—2024年2月厦门大学附属第一医院检验科收治的200例MPP患儿的病历资料和100例无器质性疾病、近1个月内未发生过急性感染的健康儿童的体检报告。200例MPP患儿作为MPP组,将其中120例重症患儿纳入A组,将80例轻症患儿纳入B组,将100例健康儿童纳入对照组。采集所有儿童静脉血,检测血清MP-IgM、25-OH-VD、IL-6水平,比较A组、B组、对照组血清MP-IgM、IL-6、25-OH-VD水平,并绘制受试者工作特征(ROC)曲线分析上述指标在临床诊断MPP严重程度中的应用价值。结果:与对照组比较,A组、B组MP-IgM、IL-6水平更高,25-OH-VD水平更低,差异有统计学意义(P<0.05);与B组比较,A组MP-IgM、IL-6水平更高,25-OH-VD水平更低,差异有统计学意义(P<0.05)。血清MP-IgM、IL-6、25-OH-D水平诊断轻重症患儿的ROC曲线下面积(AUC)分别为0.737、0.772、0.905。结论:MPP患儿血清MP-IgM、IL-6水平显著升高,血清25-OH-VD水平显著下降,上述血清指标均可反映病情严重程度,且25-OH-VD诊断价值最高。Objective:To explore the clinical application value of mycoplasma immunoglobulin M antibody(MP-IgM),25-hydroxyvitamin D(25-OH-VD)and interleukin-6(IL-6)in children with Mycoplasma pneumoniae pneumonia(MPP).Method:The medical records of 200 children with MPP who admitted to the Department of Clinical Laboratory of the First Affiliated Hospital of Xiamen University from February 2023 to February 2024 and the physical examination reports of 100 healthy children without organic diseases and without acute infection in the past one month were retrospectively analyzed.The 200 children with MPP were selected as MPP group,120 children with severe MPP were included in group A,80 children with mild MPP were included in group B,and the 100 healthy children were included in control group.Venous blood of all children were collected to detect the levels of serum MP-IgM,25-OH-VD and IL-6,the levels of serum MP-IgM,IL-6 and 25-OH-VD in group A,group B and the control group were compared,and the receiver operating characteristic(ROC)curve was drawn to analyze the application value of the above indexes in the clinical diagnosis of MPP severity.Result:Compared with the control group,the levels of MP-IgM and IL-6 in group A and group B were higher,and the levels of 25-OH-VD were lower,the differences were statistically significant(P<0.05);compared with group B,the levels of MP-IgM and IL-6 in group A were higher,and the level of 25-OH-VD was lower,the differences were statistically significant(P<0.05).The area under the ROC curve(AUC)of serum MP-IgM,IL-6 and 25-OH-D levels in the diagnosis of mild and severe children were 0.737,0.772 and 0.905,respectively.Conclusion:The levels of serum MP-IgM and IL-6 in children with MPP are increased significantly,while the level of serum 25-OH-VD is decreased significantly,the above serum indicators can reflect the severity of disease,and the diagnostic value of 25-OH-VD is the highest.

关 键 词：支原体免疫球蛋白M 抗体 25- 羟维生素D 白细胞介素-6 肺炎支原体 

分 类 号：R725.6[医药卫生—儿科]